2bjo: Difference between revisions

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<StructureSection load='2bjo' size='340' side='right'caption='[[2bjo]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='2bjo' size='340' side='right'caption='[[2bjo]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2bjo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"vibrio_subtilis"_ehrenberg_1835 "vibrio subtilis" ehrenberg 1835]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BJO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BJO FirstGlance]. <br>
<table><tr><td colspan='2'>[[2bjo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BJO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BJO FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bjo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bjo OCA], [https://pdbe.org/2bjo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bjo RCSB], [https://www.ebi.ac.uk/pdbsum/2bjo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bjo ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bjo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bjo OCA], [https://pdbe.org/2bjo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bjo RCSB], [https://www.ebi.ac.uk/pdbsum/2bjo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bjo ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/OHRB_BACSU OHRB_BACSU] Involved in organic hydroperoxide resistance.<ref>PMID:11418552</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Vibrio subtilis ehrenberg 1835]]
[[Category: Bacillus subtilis]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Bielnicki, J]]
[[Category: Bielnicki J]]
[[Category: Cooper, D R]]
[[Category: Cooper DR]]
[[Category: Derewenda, Z S]]
[[Category: Derewenda ZS]]
[[Category: Devedjiev, Y]]
[[Category: Devedjiev Y]]
[[Category: Joachimiak, A]]
[[Category: Joachimiak A]]
[[Category: Surendranath, Y]]
[[Category: Surendranath Y]]
[[Category: Heat shock protein]]
[[Category: Organic hydroperoxide resistance]]
[[Category: Oxidoreductase]]

Latest revision as of 16:41, 13 December 2023

Crystal Structure of the Organic Hydroperoxide Resistance Protein OhrB of Bacillus subtilisCrystal Structure of the Organic Hydroperoxide Resistance Protein OhrB of Bacillus subtilis

Structural highlights

2bjo is a 2 chain structure with sequence from Bacillus subtilis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.1Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

OHRB_BACSU Involved in organic hydroperoxide resistance.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The crystal structure of the fully oxidized form of the Bacillus subtilis organic hydroperoxide-resistance (OhrB) protein is reported at 2.1 A resolution. The electron density reveals an intact catalytic disulfide bond (Cys55-Cys119) in each of the two molecules, which are intertwined into a canonical obligate dimer. However, the stereochemistry of the disulfides is unorthodox and strained, suggesting that they are sensitive to reducing agents. A deep solvent-accessible gorge reaching Cys55 may represent the access route for the reductant.

Structure of the Bacillus subtilis OhrB hydroperoxide-resistance protein in a fully oxidized state.,Cooper DR, Surendranath Y, Devedjiev Y, Bielnicki J, Derewenda ZS Acta Crystallogr D Biol Crystallogr. 2007 Dec;63(Pt 12):1269-73. Epub 2007, Nov 16. PMID:18084074[2]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

See Also

References

  1. ↑ Fuangthong M, Atichartpongkul S, Mongkolsuk S, Helmann JD. OhrR is a repressor of ohrA, a key organic hydroperoxide resistance determinant in Bacillus subtilis. J Bacteriol. 2001 Jul;183(14):4134-41. PMID:11418552 doi:http://dx.doi.org/10.1128/JB.183.14.4134-4141.2001
  2. ↑ Cooper DR, Surendranath Y, Devedjiev Y, Bielnicki J, Derewenda ZS. Structure of the Bacillus subtilis OhrB hydroperoxide-resistance protein in a fully oxidized state. Acta Crystallogr D Biol Crystallogr. 2007 Dec;63(Pt 12):1269-73. Epub 2007, Nov 16. PMID:18084074 doi:10.1107/S0907444907050226

2bjo, resolution 2.10Å

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