NK cell receptor: Difference between revisions

Latest revision as of 10:43, 20 July 2023

Function

Natural killer (NK) cell receptors are located on the innate immune system NK cells. The receptors are differentiated into those activating effector function and those inhibiting it. The receptors induce apoptosis upon binding ligands which indicate infection^[1].

NKG2D is expressed in NK cells, cytotoxic T cells and T cell subsets.
NKP are CD122(+) NK cell precursors.
2B4 (CD244) are expressed on all NK cells, T cell subset, monocytes and basophils^[2].
Ly49 are lectin-type receptors expressed in NK cells and T cell subsets^[3].
KIR are immunoglobulin-type receptors^[4].

Relevance

NKG2D is associated with response to cellular distress and infection^[5].

Human NK cell receptor NKG2D (grey and green) complex with class I MHC-like ligand ULBP3 (pink) and glutathione (PDB entry 1kcg)

Drag the structure with the mouse to rotate

3D structures of NK cell receptor3D structures of NK cell receptor

Updated on 20-July-2023

ReferencesReferences

↑ Lanier LL. NK cell receptors. Annu Rev Immunol. 1998;16:359-93. PMID:9597134 doi:http://dx.doi.org/10.1146/annurev.immunol.16.1.359
↑ Mathew SO, Rao KK, Kim JR, Bambard ND, Mathew PA. Functional role of human NK cell receptor 2B4 (CD244) isoforms. Eur J Immunol. 2009 Jun;39(6):1632-41. doi: 10.1002/eji.200838733. PMID:19499526 doi:http://dx.doi.org/10.1002/eji.200838733
↑ Kane KP, Lavender KJ, Ma BJ. Ly-49 receptors and their functions. Crit Rev Immunol. 2004;24(5):321-48. PMID:15663362
↑ Norman PJ, Carrington CV, Byng M, Maxwell LD, Curran MD, Stephens HA, Chandanayingyong D, Verity DH, Hameed K, Ramdath DD, Vaughan RW. Natural killer cell immunoglobulin-like receptor (KIR) locus profiles in African and South Asian populations. Genes Immun. 2002 Apr;3(2):86-95. PMID:11960306 doi:http://dx.doi.org/10.1038/sj.gene.6363836
↑ Raulet DH. Roles of the NKG2D immunoreceptor and its ligands. Nat Rev Immunol. 2003 Oct;3(10):781-90. PMID:14523385 doi:http://dx.doi.org/10.1038/nri1199

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel

[1] Lanier LL. NK cell receptors. Annu Rev Immunol. 1998;16:359-93. PMID:9597134 doi:http://dx.doi.org/10.1146/annurev.immunol.16.1.359

[2] Mathew SO, Rao KK, Kim JR, Bambard ND, Mathew PA. Functional role of human NK cell receptor 2B4 (CD244) isoforms. Eur J Immunol. 2009 Jun;39(6):1632-41. doi: 10.1002/eji.200838733. PMID:19499526 doi:http://dx.doi.org/10.1002/eji.200838733

[3] Kane KP, Lavender KJ, Ma BJ. Ly-49 receptors and their functions. Crit Rev Immunol. 2004;24(5):321-48. PMID:15663362

[4] Norman PJ, Carrington CV, Byng M, Maxwell LD, Curran MD, Stephens HA, Chandanayingyong D, Verity DH, Hameed K, Ramdath DD, Vaughan RW. Natural killer cell immunoglobulin-like receptor (KIR) locus profiles in African and South Asian populations. Genes Immun. 2002 Apr;3(2):86-95. PMID:11960306 doi:http://dx.doi.org/10.1038/sj.gene.6363836

[5] Raulet DH. Roles of the NKG2D immunoreceptor and its ligands. Nat Rev Immunol. 2003 Oct;3(10):781-90. PMID:14523385 doi:http://dx.doi.org/10.1038/nri1199

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@@ Line 23: / Line 23: @@
 *NKG2D
-**[[1hq8]] – mNKG2D extracellular domain – mouse<br />
 **[[1mpu]] – hNKG2D extracellular domain – human<br />
-**[[1hyr]] – hNKG2D extracellular domain + class I MHC-like ligand  MICA <br />
+**[[1hyr]], [[7fi5]], [[7fi6]], [[7fi7]], [[7fi8]], [[7fi9]]  – hNKG2D extracellular domain + class I MHC-like ligand  MICA <br />
 **[[1kcg]] – hNKG2D extracellular domain + class I MHC-like ligand ULBP3<br />
 **[[4s0u]] – hNKG2D extracellular domain + retinoic acid early transcript 1L protein <br />
@@ Line 32: / Line 31: @@
 **[[3bdw]] – hNKG2D extracellular domain + CD94<br />
 **[[3bdw]], [[3cii]] – hNKG2D extracellular domain + CD94 + MHC class I antigen E + β-2-microglobulin + HLA G antigen<br />
+**[[8ea5]], [[8ea6]], [[8ea7]], [[8ea8]], [[8ea9]], [[8eaa]], [[8eab]] – hNKG2D extracellular domain + inhibitor<br />
+**[[1hq8]] – mNKG2D extracellular domain – mouse<br />
 *NKp
@@ Line 57: / Line 58: @@
 **[[3wyr]] – hKIR2dl4 extracellular domain <br />
 **[[3h8n]] – hKIR2ds4 extracellular domain <br />
-**[[3wuw]], [[5t70]], [[5t6z]], [[5b39]], [[5b38]], [[3vh8]], [[6v3j]], [[7k80]] – hKIR3dl1
+**[[3wuw]], [[5t70]], [[5t6z]], [[5b39]], [[5b38]], [[3vh8]], [[6v3j]], [[7duu]], [[7k80]] – hKIR3dl1 extracellular domain + MHC class I antigen B + β-2-microglobulin + IG κ chain C region<br />
-extracellular domain + MHC class I antigen B + β-2-microglobulin + IG κ chain C region<br />
 **[[6pag]] – hKIR3dl3 extracellular domain + MHC class I antigen B + β-2-microglobulin + peptide<br />
 **[[6pa1]] – hKIR2dl2 extracellular domain + MHC class I antigen B + β-2-microglobulin + peptide<br />