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==Crystal structure of tigecycline degrading monooxygenase Tet(X4)== | ==Crystal structure of tigecycline degrading monooxygenase Tet(X4)== | ||
<StructureSection load='7epv' size='340' side='right'caption='[[7epv]]' scene=''> | <StructureSection load='7epv' size='340' side='right'caption='[[7epv]], [[Resolution|resolution]] 1.78Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7EPV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7EPV FirstGlance]. <br> | <table><tr><td colspan='2'>[[7epv]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7EPV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7EPV FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7epv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7epv OCA], [https://pdbe.org/7epv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7epv RCSB], [https://www.ebi.ac.uk/pdbsum/7epv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7epv ProSAT]</span></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FDA:DIHYDROFLAVINE-ADENINE+DINUCLEOTIDE'>FDA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7epv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7epv OCA], [https://pdbe.org/7epv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7epv RCSB], [https://www.ebi.ac.uk/pdbsum/7epv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7epv ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[[https://www.uniprot.org/uniprot/A0A3T0V9Y5_ECOLX A0A3T0V9Y5_ECOLX]] An FAD-requiring monooxygenase active on some tetracycline antibiotic derivatives, which leads to their inactivation. Hydroxylates carbon 11a of tetracycline and some analogs.[HAMAP-Rule:MF_00845] | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Chen S]] | [[Category: Chen, S]] | ||
[[Category: Cheng Q]] | [[Category: Cheng, Q]] | ||
[[Category: Monooxygenase]] | |||
[[Category: Oxidoreductase]] | |||
[[Category: Tigecycline resistance]] | |||
Revision as of 18:35, 22 December 2021
Crystal structure of tigecycline degrading monooxygenase Tet(X4)Crystal structure of tigecycline degrading monooxygenase Tet(X4)
Structural highlights
Function[A0A3T0V9Y5_ECOLX] An FAD-requiring monooxygenase active on some tetracycline antibiotic derivatives, which leads to their inactivation. Hydroxylates carbon 11a of tetracycline and some analogs.[HAMAP-Rule:MF_00845] |
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