1fmk: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

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-[[Image:1fmk.gif|left|200px]]
+{{Seed}}
+[[Image:1fmk.png|left|200px]]
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 {{STRUCTURE_1fmk|  PDB=1fmk  |  SCENE=  }}
-'''CRYSTAL STRUCTURE OF HUMAN TYROSINE-PROTEIN KINASE C-SRC'''
+===CRYSTAL STRUCTURE OF HUMAN TYROSINE-PROTEIN KINASE C-SRC===
-==Overview==
+<!--
-The structure of a large fragment of the c-Src tyrosine kinase, comprising the regulatory and kinase domains and the carboxy-terminal tall, has been determined at 1.7 A resolution in a closed, inactive state. Interactions among domains, stabilized by binding of the phosphorylated tail to the SH2 domain, lock the molecule in a conformation that simultaneously disrupts the kinase active site and sequesters the binding surfaces of the SH2 and SH3 domains. The structure shows how appropriate cellular signals, or transforming mutations in v-Src, could break these interactions to produce an open, active kinase.
+The line below this paragraph, {{ABSTRACT_PUBMED_9024657}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 9024657 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_9024657}}
 ==About this Structure==
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 [[Category: Src]]
 [[Category: Tyrosine kinase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 16:30:20 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 03:30:01 2008''