1wsh: Difference between revisions

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<StructureSection load='1wsh' size='340' side='right'caption='[[1wsh]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='1wsh' size='340' side='right'caption='[[1wsh]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1wsh]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WSH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WSH FirstGlance]. <br>
<table><tr><td colspan='2'>[[1wsh]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WSH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WSH FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1wse|1wse]], [[1wsf|1wsf]], [[1wsg|1wsg]], [[1wsi|1wsi]], [[1wsj|1wsj]]</div></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Ribonuclease_H Ribonuclease H], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.26.4 3.1.26.4] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wsh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wsh OCA], [https://pdbe.org/1wsh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wsh RCSB], [https://www.ebi.ac.uk/pdbsum/1wsh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wsh ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wsh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wsh OCA], [https://pdbe.org/1wsh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wsh RCSB], [https://www.ebi.ac.uk/pdbsum/1wsh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wsh ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/RNH_ECOLI RNH_ECOLI]] Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. RNase H participates in DNA replication; it helps to specify the origin of genomic replication by suppressing initiation at origins other than the oriC locus; along with the 5'-3' exonuclease of pol1, it removes RNA primers from the Okazaki fragments of lagging strand synthesis; and it defines the origin of replication for ColE1-type plasmids by specific cleavage of an RNA preprimer.[HAMAP-Rule:MF_00042]  
[https://www.uniprot.org/uniprot/RNH_ECOLI RNH_ECOLI] Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. RNase H participates in DNA replication; it helps to specify the origin of genomic replication by suppressing initiation at origins other than the oriC locus; along with the 5'-3' exonuclease of pol1, it removes RNA primers from the Okazaki fragments of lagging strand synthesis; and it defines the origin of replication for ColE1-type plasmids by specific cleavage of an RNA preprimer.[HAMAP-Rule:MF_00042]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bacillus coli migula 1895]]
[[Category: Escherichia coli]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Ribonuclease H]]
[[Category: Kanaya S]]
[[Category: Kanaya, S]]
[[Category: Matsumura H]]
[[Category: Matsumura, H]]
[[Category: Takano K]]
[[Category: Takano, K]]
[[Category: Tsunaka Y]]
[[Category: Tsunaka, Y]]
[[Category: Yamagata Y]]
[[Category: Yamagata, Y]]
[[Category: Active-site mutant]]
[[Category: Hydrolase]]
[[Category: Rnase h]]

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