2vci: Difference between revisions
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<StructureSection load='2vci' size='340' side='right'caption='[[2vci]], [[Resolution|resolution]] 2.00Å' scene=''> | <StructureSection load='2vci' size='340' side='right'caption='[[2vci]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2vci]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2vci]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VCI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VCI FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2GJ:5-[2,4-DIHYDROXY-5-(1-METHYLETHYL)PHENYL]-N-ETHYL-4-[4-(MORPHOLIN-4-YLMETHYL)PHENYL]ISOXAZOLE-3-CARBOXAMIDE'>2GJ</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vci FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vci OCA], [https://pdbe.org/2vci PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vci RCSB], [https://www.ebi.ac.uk/pdbsum/2vci PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vci ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vci FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vci OCA], [https://pdbe.org/2vci PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vci RCSB], [https://www.ebi.ac.uk/pdbsum/2vci PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vci ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Aherne | [[Category: Aherne W]] | ||
[[Category: Barril | [[Category: Barril X]] | ||
[[Category: Borgognoni | [[Category: Borgognoni J]] | ||
[[Category: Boxal | [[Category: Boxal K]] | ||
[[Category: Brough | [[Category: Brough PA]] | ||
[[Category: Cansfield | [[Category: Cansfield JE]] | ||
[[Category: Cheung | [[Category: Cheung KM]] | ||
[[Category: Collins | [[Category: Collins I]] | ||
[[Category: Davies | [[Category: Davies NGM]] | ||
[[Category: Drysdale | [[Category: Drysdale MJ]] | ||
[[Category: Dymock | [[Category: Dymock B]] | ||
[[Category: Eccles | [[Category: Eccles SA]] | ||
[[Category: Finch | [[Category: Finch H]] | ||
[[Category: Fink | [[Category: Fink A]] | ||
[[Category: Hayes | [[Category: Hayes A]] | ||
[[Category: Howes | [[Category: Howes R]] | ||
[[Category: Hubbard | [[Category: Hubbard RE]] | ||
[[Category: James | [[Category: James K]] | ||
[[Category: Jordan | [[Category: Jordan AM]] | ||
[[Category: Lockie | [[Category: Lockie A]] | ||
[[Category: Martins | [[Category: Martins V]] | ||
[[Category: Massey | [[Category: Massey A]] | ||
[[Category: Matthews | [[Category: Matthews TP]] | ||
[[Category: McDonald | [[Category: McDonald E]] | ||
[[Category: Northfield | [[Category: Northfield CJ]] | ||
[[Category: Pearl | [[Category: Pearl LH]] | ||
[[Category: Prodromou | [[Category: Prodromou C]] | ||
[[Category: Ray | [[Category: Ray S]] | ||
[[Category: Raynaud | [[Category: Raynaud FI]] | ||
[[Category: Roughley | [[Category: Roughley SD]] | ||
[[Category: Sharp | [[Category: Sharp SY]] | ||
[[Category: Surgenor | [[Category: Surgenor A]] | ||
[[Category: Walmsley | [[Category: Walmsley DL]] | ||
[[Category: Webb | [[Category: Webb P]] | ||
[[Category: Wood | [[Category: Wood M]] | ||
[[Category: Workman | [[Category: Workman P]] | ||
[[Category: Wright | [[Category: Wright L]] | ||