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==Solution structure of the bromodomain of human BRPF1 in complex with histone H4K5ac peptide==
==Solution structure of the bromodomain of human BRPF1 in complex with histone H4K5ac peptide==
<StructureSection load='2rs9' size='340' side='right'caption='[[2rs9]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2rs9' size='340' side='right'caption='[[2rs9]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2rs9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RS9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RS9 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2rs9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RS9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RS9 FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2d9e|2d9e]]</div></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BRPF1, BR140 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rs9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rs9 OCA], [https://pdbe.org/2rs9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rs9 RCSB], [https://www.ebi.ac.uk/pdbsum/2rs9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rs9 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rs9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rs9 OCA], [https://pdbe.org/2rs9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rs9 RCSB], [https://www.ebi.ac.uk/pdbsum/2rs9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rs9 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/BRPF1_HUMAN BRPF1_HUMAN]] Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Positively regulates the transcription of RUNX1 and RUNX2.<ref>PMID:16387653</ref> <ref>PMID:18794358</ref> 
[https://www.uniprot.org/uniprot/H4_HUMAN H4_HUMAN]  
 
==See Also==
*[[Peregrin|Peregrin]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Hayashi, F]]
[[Category: Hayashi F]]
[[Category: Nagashima, T]]
[[Category: Nagashima T]]
[[Category: Qin, X]]
[[Category: Qin X]]
[[Category: Structural genomic]]
[[Category: Umehara T]]
[[Category: Umehara, T]]
[[Category: Yokoyama S]]
[[Category: Yokoyama, S]]
[[Category: Br140 protein]]
[[Category: Bromodomain and phd finger-containing protein 1]]
[[Category: Histone]]
[[Category: Human brpf1 protein]]
[[Category: National project on protein structural and functional analyse]]
[[Category: Nppsfa]]
[[Category: Rsgi]]
[[Category: Transcription]]
[[Category: Transcription activator]]

Revision as of 13:03, 14 June 2023

Solution structure of the bromodomain of human BRPF1 in complex with histone H4K5ac peptideSolution structure of the bromodomain of human BRPF1 in complex with histone H4K5ac peptide

Structural highlights

2rs9 is a 2 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

H4_HUMAN

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
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