2nqa: Difference between revisions
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<StructureSection load='2nqa' size='340' side='right'caption='[[2nqa]], [[Resolution|resolution]] 2.20Å' scene=''> | <StructureSection load='2nqa' size='340' side='right'caption='[[2nqa]], [[Resolution|resolution]] 2.20Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2nqa]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2nqa]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Streptomyces_roseus Streptomyces roseus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NQA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NQA FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=AR7:AMINO{[(4S)-4-AMINO-5,5-DIHYDROXYPENTYL]AMINO}METHANIMINIUM'>AR7</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nqa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nqa OCA], [https://pdbe.org/2nqa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nqa RCSB], [https://www.ebi.ac.uk/pdbsum/2nqa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nqa ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nqa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nqa OCA], [https://pdbe.org/2nqa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nqa RCSB], [https://www.ebi.ac.uk/pdbsum/2nqa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nqa ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[[https://www.uniprot.org/uniprot/CAN8_HUMAN CAN8_HUMAN | [https://www.uniprot.org/uniprot/CAN2_HUMAN CAN2_HUMAN] Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.[https://www.uniprot.org/uniprot/CAN8_HUMAN CAN8_HUMAN] Calcium-regulated non-lysosomal thiol-protease. Involved in membrane trafficking in the gastric surface mucus cells (pit cells) and may involve the membrane trafficking of mucus cells via interactions with coat protein. Proteolytically cleaves the beta-subunit of coatomer complex (By similarity). | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Arrowsmith | [[Category: Streptomyces roseus]] | ||
[[Category: Bochkarev | [[Category: Arrowsmith CH]] | ||
[[Category: Butler-Cole | [[Category: Bochkarev A]] | ||
[[Category: Davis | [[Category: Butler-Cole C]] | ||
[[Category: Dhe-Paganon | [[Category: Davis TL]] | ||
[[Category: Edwards | [[Category: Dhe-Paganon S]] | ||
[[Category: Finerty | [[Category: Edwards AM]] | ||
[[Category: Paramanathan | [[Category: Finerty Jr PJ]] | ||
[[Category: Paramanathan R]] | |||
[[Category: Sundstrom | [[Category: Sundstrom M]] | ||
[[Category: Weigelt | [[Category: Weigelt J]] | ||