1fi8: Difference between revisions

Revision as of 03:17, 1 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1fi8.png

Template:STRUCTURE 1fi8

RAT GRANZYME B [N66Q] COMPLEXED TO ECOTIN [81-84 IEPD]RAT GRANZYME B [N66Q] COMPLEXED TO ECOTIN [81-84 IEPD]

Template:ABSTRACT PUBMED 10966646

About this StructureAbout this Structure

1FI8 is a Protein complex structure of sequences from Escherichia coli and Rattus norvegicus. Full crystallographic information is available from OCA.

ReferenceReference

The structure of the pro-apoptotic protease granzyme B reveals the molecular determinants of its specificity., Waugh SM, Harris JL, Fletterick R, Craik CS, Nat Struct Biol. 2000 Sep;7(9):762-5. PMID:10966646

Page seeded by OCA on Tue Jul 1 03:17:16 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:1fi8.gif|left|200px]]
+{{Seed}}
+[[Image:1fi8.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_1fi8|  PDB=1fi8  |  SCENE=  }}
-'''RAT GRANZYME B [N66Q] COMPLEXED TO ECOTIN [81-84 IEPD]'''
+===RAT GRANZYME B [N66Q] COMPLEXED TO ECOTIN [81-84 IEPD]===
-==Overview==
+<!--
-Granzyme B is a serine protease of the chymotrypsin fold that mediates cell death by cytotoxic lymphocytes. It is a processing enzyme, requiring extended peptide substrates containing an Asp residue. The determinants that allow for this substrate specificity are revealed in the three-dimensional structure of granzyme B in complex with a macromolecular inhibitor. The primary specificity for Asp occurs through a side-on interaction with Arg 226, a buried Arg side chain of granzyme B. An additional nine amino acids make contact with the substrate and define the granzyme B extended substrate specificity profile. The substrate determinants found in this structure are shared by other members of this protein class and help to reveal the properties that define substrate specificity.
+The line below this paragraph, {{ABSTRACT_PUBMED_10966646}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 10966646 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_10966646}}
 ==About this Structure==
@@ Line 32: / Line 36: @@
 [[Category: Granzyme b]]
 [[Category: Protease substrate interaction]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 16:21:35 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 03:17:16 2008''