2cay: Difference between revisions
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<StructureSection load='2cay' size='340' side='right'caption='[[2cay]], [[Resolution|resolution]] 1.90Å' scene=''> | <StructureSection load='2cay' size='340' side='right'caption='[[2cay]], [[Resolution|resolution]] 1.90Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2cay]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2cay]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CAY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CAY FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cay FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cay OCA], [https://pdbe.org/2cay PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cay RCSB], [https://www.ebi.ac.uk/pdbsum/2cay PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cay ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cay FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cay OCA], [https://pdbe.org/2cay PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cay RCSB], [https://www.ebi.ac.uk/pdbsum/2cay PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cay ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/VPS36_YEAST VPS36_YEAST] Component of the ESCRT-II complex, which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Involved in the trafficking of the plasma membrane ATPase. Its ability to bind ubiquitin plays a central role in endosomal sorting of ubiquitinated cargo proteins by the ESCRT complexes.<ref>PMID:12194858</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Saccharomyces cerevisiae]] | ||
[[Category: | [[Category: Gill DJ]] | ||
[[Category: | [[Category: Perisic O]] | ||
[[Category: | [[Category: Teo H]] | ||
[[Category: | [[Category: Williams RL]] | ||