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==Pseudomonas aeruginosa DNA gyrase B 24kDa ATPase subdomain complexed with EBL2888== | |||
<StructureSection load='7ptg' size='340' side='right'caption='[[7ptg]], [[Resolution|resolution]] 2.20Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7ptg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7PTG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7PTG FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=80S:2-[[3,4-bis(chloranyl)-5-methyl-1H-pyrrol-2-yl]carbonylamino]-4-[(1S)-1-phenylethoxy]-1,3-benzothiazole-6-carboxylic+acid'>80S</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ptg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ptg OCA], [https://pdbe.org/7ptg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ptg RCSB], [https://www.ebi.ac.uk/pdbsum/7ptg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ptg ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/GYRB_PSEAE GYRB_PSEAE] A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Pseudomonas aeruginosa PAO1]] | |||
[[Category: Burton N]] | |||
[[Category: Cotman AE]] | |||
[[Category: Ilas J]] | |||
[[Category: Kikelj D]] | |||
[[Category: Lawson DM]] | |||
[[Category: Masic LP]] | |||
[[Category: Maxwell A]] | |||
[[Category: Mundy JEA]] | |||
[[Category: Stevenson CEM]] | |||
[[Category: Tomasic T]] | |||
[[Category: Zega A]] | |||
[[Category: Zidar N]] | |||
Revision as of 12:37, 19 April 2023
Pseudomonas aeruginosa DNA gyrase B 24kDa ATPase subdomain complexed with EBL2888Pseudomonas aeruginosa DNA gyrase B 24kDa ATPase subdomain complexed with EBL2888
Structural highlights
FunctionGYRB_PSEAE A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. |
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