3k83: Difference between revisions
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<StructureSection load='3k83' size='340' side='right'caption='[[3k83]], [[Resolution|resolution]] 2.25Å' scene=''> | <StructureSection load='3k83' size='340' side='right'caption='[[3k83]], [[Resolution|resolution]] 2.25Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3k83]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[3k83]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K83 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3K83 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1DO:1-DODECANOL'>1DO</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=F27:6-[2-(3-BIPHENYL-4-YLPROPANOYL)-1,3-OXAZOL-5-YL]PYRIDINE-2-CARBOXYLIC+ACID'>F27</scene> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.251Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1DO:1-DODECANOL'>1DO</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=F27:6-[2-(3-BIPHENYL-4-YLPROPANOYL)-1,3-OXAZOL-5-YL]PYRIDINE-2-CARBOXYLIC+ACID'>F27</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3k83 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k83 OCA], [https://pdbe.org/3k83 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3k83 RCSB], [https://www.ebi.ac.uk/pdbsum/3k83 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3k83 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3k83 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k83 OCA], [https://pdbe.org/3k83 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3k83 RCSB], [https://www.ebi.ac.uk/pdbsum/3k83 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3k83 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/FAAH1_RAT FAAH1_RAT] Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates (By similarity). | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Rattus norvegicus]] | ||
[[Category: | [[Category: Boger DL]] | ||
[[Category: | [[Category: Mileni M]] | ||
[[Category: | [[Category: Stevens RC]] | ||