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| {{STRUCTURE_1fch| PDB=1fch | SCENE= }} | | {{STRUCTURE_1fch| PDB=1fch | SCENE= }} |
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| '''CRYSTAL STRUCTURE OF THE PTS1 COMPLEXED TO THE TPR REGION OF HUMAN PEX5'''
| | ===CRYSTAL STRUCTURE OF THE PTS1 COMPLEXED TO THE TPR REGION OF HUMAN PEX5=== |
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| ==Overview==
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| Many proteins contain targeting signals within their sequences that specify their delivery to particular organelles. The peroxisomal targeting signal-1 (PTS1) is a C-terminal tripeptide that is sufficient to direct proteins into peroxisomes. The PTS1 sequence closely approximates Ser-Lys-Leu-COO-. PEX5, the receptor for PTS1, interacts with the signal via a series of tetratricopeptide repeats (TPRs) within its C-terminal half. Here we report the crystal structure of a fragment of human PEX5 that includes all seven predicted TPR motifs in complex with a pentapeptide containing a PTS1 sequence. Two clusters of three TPRs almost completely surround the peptide, while a hinge region, previously identified as TPR4, forms a distinct structure that enables the two sets of TPRs to form a single binding site. This structure reveals the molecular basis for PTS1 recognition and demonstrates a novel mode of TPR-peptide interaction.
| | The line below this paragraph, {{ABSTRACT_PUBMED_11101887}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 11101887 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_11101887}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Tetratricopeptide repeat]] | | [[Category: Tetratricopeptide repeat]] |
| [[Category: Tpr]] | | [[Category: Tpr]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:10:17 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:02:52 2008'' |