1rxd: Difference between revisions
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==Crystal structure of human protein tyrosine phosphatase 4A1== | ==Crystal structure of human protein tyrosine phosphatase 4A1== | ||
<StructureSection load='1rxd' size='340' side='right'caption='[[1rxd]]' scene=''> | <StructureSection load='1rxd' size='340' side='right'caption='[[1rxd]], [[Resolution|resolution]] 1.90Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RXD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RXD FirstGlance]. <br> | <table><tr><td colspan='2'>[[1rxd]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RXD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RXD FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rxd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rxd OCA], [https://pdbe.org/1rxd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rxd RCSB], [https://www.ebi.ac.uk/pdbsum/1rxd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rxd ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/1rxd TOPSAN]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rxd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rxd OCA], [https://pdbe.org/1rxd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rxd RCSB], [https://www.ebi.ac.uk/pdbsum/1rxd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rxd ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/1rxd TOPSAN]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/TP4A1_HUMAN TP4A1_HUMAN] Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis.<ref>PMID:12235145</ref> <ref>PMID:14643450</ref> <ref>PMID:12782572</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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*[[Dual specificity phosphatase 3D structures|Dual specificity phosphatase 3D structures]] | *[[Dual specificity phosphatase 3D structures|Dual specificity phosphatase 3D structures]] | ||
*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]] | *[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]] | ||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Almo SC]] | [[Category: Almo SC]] | ||