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==NMR STRUCTURE OF THE C-TERMINAL DOMAIN OF THE LIGAND-BINDING REGION OF MURINE GRANULOCYTE COLONY-STIMULATING FACTOR RECEPTOR, MINIMIZED AVERAGE STRUCTURE==
==NMR STRUCTURE OF THE C-TERMINAL DOMAIN OF THE LIGAND-BINDING REGION OF MURINE GRANULOCYTE COLONY-STIMULATING FACTOR RECEPTOR, MINIMIZED AVERAGE STRUCTURE==
<StructureSection load='1cto' size='340' side='right'caption='[[1cto]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''>
<StructureSection load='1cto' size='340' side='right'caption='[[1cto]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1cto]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CTO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CTO FirstGlance]. <br>
<table><tr><td colspan='2'>[[1cto]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CTO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CTO FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cto FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cto OCA], [https://pdbe.org/1cto PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cto RCSB], [https://www.ebi.ac.uk/pdbsum/1cto PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cto ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cto FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cto OCA], [https://pdbe.org/1cto PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cto RCSB], [https://www.ebi.ac.uk/pdbsum/1cto PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cto ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/CSF3R_MOUSE CSF3R_MOUSE]] Receptor for granulocyte colony-stimulating factor (CSF3). In addition it may function in some adhesion or recognition events at the cell surface.  
[https://www.uniprot.org/uniprot/CSF3R_MOUSE CSF3R_MOUSE] Receptor for granulocyte colony-stimulating factor (CSF3). In addition it may function in some adhesion or recognition events at the cell surface.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1cto ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1cto ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
We have determined the NMR structure of a ligand-binding domain of the granulocyte colony-stimulating factor (G-CSF) receptor, containing the highly conserved WSxWS motif. The domain consists of seven beta-strands with the fibronectin type III-like topology seen in several cytokine receptors. Comparisons between the spectra of the 15N-labelled domain with and without G-CSF indicate that the major ligand-recognition site is on the FG loop just upstream of the WSxWS sequence, and not on the BC loop which is mainly used in the growth hormone system. The WSxWS residues are suggested to contribute to ligand-recognition and to the protein architecture of the G-CSF receptor.
Solution structure of an extracellular domain containing the WSxWS motif of the granulocyte colony-stimulating factor receptor and its interaction with ligand.,Yamasaki K, Naito S, Anaguchi H, Ohkubo T, Ota Y Nat Struct Biol. 1997 Jun;4(6):498-504. PMID:9187659<ref>PMID:9187659</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1cto" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Colony-stimulating factor 3D structures|Colony-stimulating factor 3D structures]]
*[[Colony-stimulating factor 3D structures|Colony-stimulating factor 3D structures]]
*[[Colony-stimulating factor receptor 3D structures|Colony-stimulating factor receptor 3D structures]]
*[[Colony-stimulating factor receptor 3D structures|Colony-stimulating factor receptor 3D structures]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Lk3 transgenic mice]]
[[Category: Mus musculus]]
[[Category: Anaguchi, H]]
[[Category: Anaguchi H]]
[[Category: Naito, S]]
[[Category: Naito S]]
[[Category: Ohkubo, T]]
[[Category: Ohkubo T]]
[[Category: Ota, Y]]
[[Category: Ota Y]]
[[Category: Yamasaki, K]]
[[Category: Yamasaki K]]
[[Category: Binding protein]]
[[Category: Cytokine receptor]]

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