1qac: Difference between revisions
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<StructureSection load='1qac' size='340' side='right'caption='[[1qac]], [[Resolution|resolution]] 1.80Å' scene=''> | <StructureSection load='1qac' size='340' side='right'caption='[[1qac]], [[Resolution|resolution]] 1.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1qac]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[1qac]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QAC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QAC FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qac FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qac OCA], [https://pdbe.org/1qac PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qac RCSB], [https://www.ebi.ac.uk/pdbsum/1qac PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qac ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qac FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qac OCA], [https://pdbe.org/1qac PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qac RCSB], [https://www.ebi.ac.uk/pdbsum/1qac PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qac ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/KV401_HUMAN KV401_HUMAN] V segment of the variable domain of immunoglobulins light chain that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).<ref>PMID:17576170</ref> <ref>PMID:20176268</ref> <ref>PMID:22158414</ref> <ref>PMID:24600447</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Cai | [[Category: Cai X]] | ||
[[Category: Johnson | [[Category: Johnson G]] | ||
[[Category: Pokkuluri | [[Category: Pokkuluri PR]] | ||
[[Category: Schiffer | [[Category: Schiffer M]] | ||
[[Category: Stevens | [[Category: Stevens FJ]] | ||