1bv8: Difference between revisions
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'''RECEPTOR DOMAIN FROM ALPHA-2-MACROGLOBULIN'''<br /> | '''RECEPTOR DOMAIN FROM ALPHA-2-MACROGLOBULIN'''<br /> | ||
==Overview== | ==Overview== | ||
The low density lipoprotein receptor-related protein is a member of the | The low density lipoprotein receptor-related protein is a member of the low density lipoprotein receptor family and contains clusters of cysteine-rich complement-like repeats of about 42 residues that are present in all members of this family of receptors. These clusters are thought to be the principal binding sites for protein ligands. We have expressed one complement-like repeat, CR8, from the cluster in lipoprotein receptor-related protein that binds certain proteinase inhibitor-proteinase complexes and used three-dimensional NMR on the 13C/15N-labeled protein to determine the structure in solution of the calcium-bound form. The structure is very similar in overall fold to repeat 5 from the low density lipoprotein receptor (LB5), with backbone root mean square deviation of 1.5 A. The calcium-binding site also appears to be homologous, with four carboxyl and two backbone carbonyl ligands. However, differences in primary structure are such that equivalent surfaces that might represent the binding interfaces are very different from one another, indicating that different domains will have very different ligand specificities. | ||
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
1BV8 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | 1BV8 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BV8 OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Dolmer, K.]] | [[Category: Dolmer, K.]] | ||
[[Category: Gettins, P | [[Category: Gettins, P G.W.]] | ||
[[Category: Huang, W.]] | [[Category: Huang, W.]] | ||
[[Category: Liao, X.]] | [[Category: Liao, X.]] | ||
[[Category: proteinase]] | [[Category: proteinase]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:59:25 2008'' | ||
Revision as of 12:59, 21 February 2008
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RECEPTOR DOMAIN FROM ALPHA-2-MACROGLOBULIN
OverviewOverview
The low density lipoprotein receptor-related protein is a member of the low density lipoprotein receptor family and contains clusters of cysteine-rich complement-like repeats of about 42 residues that are present in all members of this family of receptors. These clusters are thought to be the principal binding sites for protein ligands. We have expressed one complement-like repeat, CR8, from the cluster in lipoprotein receptor-related protein that binds certain proteinase inhibitor-proteinase complexes and used three-dimensional NMR on the 13C/15N-labeled protein to determine the structure in solution of the calcium-bound form. The structure is very similar in overall fold to repeat 5 from the low density lipoprotein receptor (LB5), with backbone root mean square deviation of 1.5 A. The calcium-binding site also appears to be homologous, with four carboxyl and two backbone carbonyl ligands. However, differences in primary structure are such that equivalent surfaces that might represent the binding interfaces are very different from one another, indicating that different domains will have very different ligand specificities.
DiseaseDisease
Known diseases associated with this structure: Alzheimer disease, susceptibility to OMIM:[103950], Emphysema due to alpha-2-macroglobulin deficiency OMIM:[103950]
About this StructureAbout this Structure
1BV8 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
NMR solution structure of complement-like repeat CR8 from the low density lipoprotein receptor-related protein., Huang W, Dolmer K, Gettins PG, J Biol Chem. 1999 May 14;274(20):14130-6. PMID:10318830
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