|
|
| Line 1: |
Line 1: |
| [[Image:1f5q.gif|left|200px]] | | {{Seed}} |
| | [[Image:1f5q.png|left|200px]] |
|
| |
|
| <!-- | | <!-- |
| Line 9: |
Line 10: |
| {{STRUCTURE_1f5q| PDB=1f5q | SCENE= }} | | {{STRUCTURE_1f5q| PDB=1f5q | SCENE= }} |
|
| |
|
| '''CRYSTAL STRUCTURE OF MURINE GAMMA HERPESVIRUS CYCLIN COMPLEXED TO HUMAN CYCLIN DEPENDENT KINASE 2'''
| | ===CRYSTAL STRUCTURE OF MURINE GAMMA HERPESVIRUS CYCLIN COMPLEXED TO HUMAN CYCLIN DEPENDENT KINASE 2=== |
|
| |
|
|
| |
|
| ==Overview==
| | <!-- |
| Several gamma-herpesviruses encode proteins related to the mammalian cyclins, regulatory subunits of cyclin-dependent kinases (cdks) essential for cell cycle progression. We report a 2.5 A crystal structure of a full-length oncogenic viral cyclin from gamma-herpesvirus 68 complexed with cdk2. The viral cyclin binds cdk2 with an orientation different from cyclin A and makes several novel interactions at the interface, yet it activates cdk2 by triggering conformational changes similar to cyclin A. Sequences within the viral cyclin N-terminus lock part of the cdk2 T-loop within the core of the complex. These sequences and others are conserved amongst the viral and cellular D-type cyclins, suggesting that this structure has wider implications for other cyclin-cdk complexes. The observed resistance of this viral cyclin-cdk complex to inhibition by the p27(KIP:) cdk inhibitor is explained by sequence and conformational variation in the cyclin rendering the p27(KIP:)-binding site on the cyclin subunit non-functional.
| | The line below this paragraph, {{ABSTRACT_PUBMED_10856233}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 10856233 is the PubMed ID number. |
| | --> |
| | {{ABSTRACT_PUBMED_10856233}} |
|
| |
|
| ==About this Structure== | | ==About this Structure== |
| Line 30: |
Line 34: |
| [[Category: Cyclin dependent kinase. protein/protein complex]] | | [[Category: Cyclin dependent kinase. protein/protein complex]] |
| [[Category: Herpesviral cyclin]] | | [[Category: Herpesviral cyclin]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:56:05 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:44:29 2008'' |