1l7r: Difference between revisions

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<StructureSection load='1l7r' size='340' side='right'caption='[[1l7r]], [[Resolution|resolution]] 1.64&Aring;' scene=''>
<StructureSection load='1l7r' size='340' side='right'caption='[[1l7r]], [[Resolution|resolution]] 1.64&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1l7r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Corynebacterium_sp._atcc_49955 Corynebacterium sp. atcc 49955]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L7R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L7R FirstGlance]. <br>
<table><tr><td colspan='2'>[[1l7r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rhodococcus_sp._MB1 Rhodococcus sp. MB1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L7R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L7R FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1ju3|1ju3]], [[1ju4|1ju4]], [[1l7q|1l7q]]</div></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.64&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Carboxylesterase Carboxylesterase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.1 3.1.1.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l7r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l7r OCA], [https://pdbe.org/1l7r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l7r RCSB], [https://www.ebi.ac.uk/pdbsum/1l7r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l7r ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l7r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l7r OCA], [https://pdbe.org/1l7r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l7r RCSB], [https://www.ebi.ac.uk/pdbsum/1l7r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l7r ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/COCE_RHOSM COCE_RHOSM]] Hydrolyzes cocaine to benzoate and ecgonine methyl ester, endowing the bacteria with the ability to utilize cocaine as a sole source of carbon and energy for growth, as this bacterium lives in the rhizosphere of coca plants. Also efficiently hydrolyzes cocaethylene, a more potent cocaine metabolite that has been observed in patients who concurrently abuse cocaine and alcohol. Is able to prevent cocaine-induced convulsions and lethality in rat.<ref>PMID:10698749</ref> <ref>PMID:16968810</ref> <ref>PMID:12369817</ref>
[https://www.uniprot.org/uniprot/COCE_RHOSM COCE_RHOSM] Hydrolyzes cocaine to benzoate and ecgonine methyl ester, endowing the bacteria with the ability to utilize cocaine as a sole source of carbon and energy for growth, as this bacterium lives in the rhizosphere of coca plants. Also efficiently hydrolyzes cocaethylene, a more potent cocaine metabolite that has been observed in patients who concurrently abuse cocaine and alcohol. Is able to prevent cocaine-induced convulsions and lethality in rat.<ref>PMID:10698749</ref> <ref>PMID:16968810</ref> <ref>PMID:12369817</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Carboxylesterase]]
[[Category: Corynebacterium sp. atcc 49955]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Basran, A]]
[[Category: Rhodococcus sp. MB1]]
[[Category: Bruce, N C]]
[[Category: Barbas III CF]]
[[Category: III, C F.Barbas]]
[[Category: Basran A]]
[[Category: Larsen, N A]]
[[Category: Bruce NC]]
[[Category: Lerner, R A]]
[[Category: Larsen NA]]
[[Category: Turner, J M]]
[[Category: Lerner RA]]
[[Category: Wilson, I A]]
[[Category: Turner JM]]
[[Category: Bacterial cocaine esterase. mutant of oxyanion hole. hydrolase]]
[[Category: Wilson IA]]
[[Category: Hydrolase]]

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