1kxl: Difference between revisions

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 ==Solution Structure of the Cdc13 DNA-binding Domain in a Complex with Single-Stranded Telomeric DNA (DNA structure not modeled)==
-<StructureSection load='1kxl' size='340' side='right'caption='[[1kxl]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
+<StructureSection load='1kxl' size='340' side='right'caption='[[1kxl]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1kxl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KXL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KXL FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1kxl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KXL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KXL FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kxl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kxl OCA], [https://pdbe.org/1kxl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kxl RCSB], [https://www.ebi.ac.uk/pdbsum/1kxl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kxl ProSAT]</span></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kxl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kxl OCA], [https://pdbe.org/1kxl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kxl RCSB], [https://www.ebi.ac.uk/pdbsum/1kxl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kxl ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[https://www.uniprot.org/uniprot/CDC13_YEAST CDC13_YEAST]] Single-stranded telomeric DNA-binding protein that regulates telomere replication. Has a role in both positive and negative regulation. Promotes [TG(1-3)] strand lengthening via interaction with EST1. Promotes [C(1-3)A] strand re-synthesis by DNA polymerase alpha via interaction with POL1. Negatively regulates telomere elongation of the G strand via binding with STN1 thereby inhibiting telomerase activity.<ref>PMID:11230149</ref> <ref>PMID:11390652</ref> <ref>PMID:10898792</ref>
+[https://www.uniprot.org/uniprot/CDC13_YEAST CDC13_YEAST] Single-stranded telomeric DNA-binding protein that regulates telomere replication. Has a role in both positive and negative regulation. Promotes [TG(1-3)] strand lengthening via interaction with EST1. Promotes [C(1-3)A] strand re-synthesis by DNA polymerase alpha via interaction with POL1. Negatively regulates telomere elongation of the G strand via binding with STN1 thereby inhibiting telomerase activity.<ref>PMID:11230149</ref> <ref>PMID:11390652</ref> <ref>PMID:10898792</ref>
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
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 </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1kxl ConSurf].
 <div style="clear:both"></div>
-<div style="background-color:#fffaf0;">
-== Publication Abstract from PubMed ==
-The essential Cdc13 protein in the yeast Saccharomyces cerevisiae is a single-stranded telomeric DNA binding protein required for chromosome end protection and telomere replication. Here we report the solution structure of the Cdc13 DNA binding domain in complex with telomeric DNA. The structure reveals the use of a single OB (oligonucleotide/oligosaccharide binding) fold augmented by an unusually large loop for DNA recognition. This OB fold is structurally similar to OB folds found in the ciliated protozoan telomere end-binding protein, although no sequence similarity is apparent between them. The common usage of an OB fold for telomeric DNA interaction demonstrates conservation of end-protection mechanisms among eukaryotes.
-Conserved structure for single-stranded telomeric DNA recognition.,Mitton-Fry RM, Anderson EM, Hughes TR, Lundblad V, Wuttke DS Science. 2002 Apr 5;296(5565):145-7. PMID:11935027<ref>PMID:11935027</ref>
-From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-</div>
-<div class="pdbe-citations 1kxl" style="background-color:#fffaf0;"></div>
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Atcc 18824]]
 [[Category: Large Structures]]
-[[Category: Anderson, E M]]
+[[Category: Saccharomyces cerevisiae]]
-[[Category: Mitton-Fry, R M]]
+[[Category: Anderson EM]]
-[[Category: Wuttke, D S]]
+[[Category: Mitton-Fry RM]]
-[[Category: Cell cycle]]
+[[Category: Wuttke DS]]
-[[Category: Dna-binding domain]]
-[[Category: Ob fold]]
-[[Category: Single-stranded dna]]
-[[Category: Telomere]]