1bo0: Difference between revisions
New page: left|200px<br /> <applet load="1bo0" size="450" color="white" frame="true" align="right" spinBox="true" caption="1bo0" /> '''MONOCYTE CHEMOATTRACTANT PROTEIN-3, NMR, MI... |
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'''MONOCYTE CHEMOATTRACTANT PROTEIN-3, NMR, MINIMIZED AVERAGE STRUCTURE'''<br /> | '''MONOCYTE CHEMOATTRACTANT PROTEIN-3, NMR, MINIMIZED AVERAGE STRUCTURE'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
1BO0 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | 1BO0 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BO0 OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: chemotactic cytokine]] | [[Category: chemotactic cytokine]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 15:33:00 2008'' | ||
Revision as of 16:33, 15 February 2008
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MONOCYTE CHEMOATTRACTANT PROTEIN-3, NMR, MINIMIZED AVERAGE STRUCTURE
OverviewOverview
1H-NMR spectroscopy and analytical ultracentrifugation studies reveal that, monocyte chemoattractant protein-3 (MCP-3) is a monomer. NMR solution, structure shows that MCP-3 adopts an alphabeta fold similar to what is, observed in structures of other known chemokines. However, MCP-3 is unique, in that it does not show a propensity to form dimers. The closely related, chemokines MCP-1 and MCP-2 show a monomer-dimer equilibrium in, sedimentation equilibrium studies (approximately 0.2-2 mg/ml). As these, proteins are present at nanomolar concentrations in vivo, the results, suggest that they are monomeric at functional concentrations and that the, monomer is the functionally significant form of MCP-1, MCP-2 and MCP-3.
About this StructureAbout this Structure
1BO0 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
Structural characterization of a monomeric chemokine: monocyte chemoattractant protein-3., Kim KS, Rajarathnam K, Clark-Lewis I, Sykes BD, FEBS Lett. 1996 Oct 21;395(2-3):277-82. PMID:8898111
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