Highest impact structures: Difference between revisions
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* '''2007 and 2011 - [[G protein-coupled receptor]]''': In 2007 the structure of the first ligand-activated G protein-coupled receptor and in 2011 the first activated G protein-coupled receptor bound to its G protein. This is a large class of proteins that have great importance as targets for drug development; it is estimated that 4% of the human genome devoted to protein coding encodes this class of proteins. The determination of the structures lead to Brian Kobilika sharing the [[Nobel_Prizes_for_3D_Molecular_Structure#Twenty-First_Century|2012 Nobel Prize in Chemistry]] | * '''2007 and 2011 - [[G protein-coupled receptor]]''': In 2007 the structure of the first ligand-activated G protein-coupled receptor and in 2011 the first activated G protein-coupled receptor bound to its G protein. This is a large class of proteins that have great importance as targets for drug development; it is estimated that 4% of the human genome devoted to protein coding encodes this class of proteins. The determination of the structures lead to Brian Kobilika sharing the [[Nobel_Prizes_for_3D_Molecular_Structure#Twenty-First_Century|2012 Nobel Prize in Chemistry]] | ||
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* '''2019 - Cytochrome nanowires''': [[6ef8]] was the first structure of an electrically-conductive bacterial protein nanowire, confirmed by [[6nef]]. Such nanowires appear to be important in global carbon and metal redox phenomena in anoxic soils and sediments, and have many possible applications<ref>PMID: 24863901</ref><ref>PMID:27801905</ref><ref>PMID: 31240257</ref>. Prior to these [[cryo-EM]] structures, it had been believed for over a decade that nanowires were type IV pili assembled from pilA<ref>PMID: 30951668</ref>. These structures surprisingly revealed nanowires as polymers of 6-heme C-type cytochromes, which called this belief into question. The unexpected protein making up these nanowires was determined from the cryo-EM density map. This is an unusual case in which the protein making up an extensively-studied organelle was not known prior to solving its atomic-level structure. | * '''2019 - Cytochrome nanowires''': [[6ef8]] was the first structure of an electrically-conductive bacterial protein nanowire, confirmed by [[6nef]]. Such nanowires appear to be important in global carbon and metal redox phenomena in anoxic soils and sediments, and have many possible applications<ref>PMID: 24863901</ref><ref>PMID:27801905</ref><ref>PMID: 31240257</ref>. Prior to these [[cryo-EM]] structures, it had been believed for over a decade that nanowires were type IV pili assembled from pilA<ref>PMID: 30951668</ref>. These structures surprisingly revealed nanowires as polymers of 6-heme C-type cytochromes, which called this belief into question. The unexpected protein making up these nanowires was determined from the cryo-EM density map. This is an unusual case in which the protein making up an extensively-studied organelle was not known prior to solving its atomic-level structure. | ||
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==Structures Saving The Most Lives== | ==Structures Saving The Most Lives== | ||