Growth factors: Difference between revisions

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Alexander Berchansky

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 *[[Platelet-derived growth factors and receptors]]. Platelet-derived growth factor receptor belongs to [[Receptor tyrosine kinases]], class III.
-*[[Tumor necrosis factor]]
+*[[Tumor necrosis factor]] and [[Tumor necrosis factor ligand superfamily]]
 The biological assembly of human tumor necrosis factor is <scene name='55/551212/Cv/4'>homotetramer</scene> (PDB entry [[2az5]]). <scene name='55/551212/Cv/5'>Inhibitor binding site</scene>.
+**[[TRAIL|TRAIL (TNF-related apoptosis-inducing ligand) or TNF ligand superfamily 10]]
+'''TRAIL-R2''' is called '''DR5'''. <scene name='48/480878/Cv/3'>TRAIL trimer residues complex with death receptor-5 extracellular domain</scene> ([[1d0g]]).
 **[[Tumor necrosis factor receptor]]
-**[[Tumor necrosis factor ligand superfamily]]
 The extracellular domain of TNFR contains 2 to 6 cysteine-rich domains (CRD). The <scene name='59/590824/Cv/8'>CRD domains are ca. 40 amino-acid long and contain 4-6 cysteine residues</scene>. The CRDs are involved in binding of TNF<ref>PMID:8939750</ref>. <scene name='59/590824/Cv/9'>Mg coordination site</scene>. Water molecules are shown as red spheres.
-**[[TRAIL|TRAIL (TNF-related apoptosis-inducing ligand) or TNF ligand superfamily 10]]
-'''TRAIL-R2''' is called '''DR5'''. <scene name='48/480878/Cv/3'>TRAIL trimer residues complex with death receptor-5 extracellular domain</scene> ([[1d0g]]).
 *[[Vascular Endothelial Growth Factor]] and [[Vascular Endothelial Growth Factor Receptor]] (VEGFR). VEGFR belongs to [[Receptor tyrosine kinases]], class IV.