1bj8: Difference between revisions
New page: left|200px<br /> <applet load="1bj8" size="450" color="white" frame="true" align="right" spinBox="true" caption="1bj8" /> '''THIRD N-TERMINAL DOMAIN OF GP130, NMR, MINI... |
No edit summary |
||
| Line 1: | Line 1: | ||
[[Image:1bj8.gif|left|200px]]<br /> | [[Image:1bj8.gif|left|200px]]<br /><applet load="1bj8" size="350" color="white" frame="true" align="right" spinBox="true" | ||
<applet load="1bj8" size=" | |||
caption="1bj8" /> | caption="1bj8" /> | ||
'''THIRD N-TERMINAL DOMAIN OF GP130, NMR, MINIMIZED AVERAGE STRUCTURE'''<br /> | '''THIRD N-TERMINAL DOMAIN OF GP130, NMR, MINIMIZED AVERAGE STRUCTURE'''<br /> | ||
==Overview== | ==Overview== | ||
The transmembrane glycoprotein gp130 is the common signal transducing | The transmembrane glycoprotein gp130 is the common signal transducing receptor subunit of the interleukin-6-type cytokines. It is a member of the cytokine-receptor superfamily predicted to consist of six domains in its extracellular part. The second and third domain constitute the cytokine-binding module defined by a set of four conserved cysteines and a WSXWS motif, respectively. The three-dimensional structure of the carboxy-terminal domain of this region was determined by multidimensional NMR. The domain consists of seven beta-strands constituting a fibronectin type III-like topology. The structure reveals that the WSDWS motif of gp130 is part of an extended tryptophan/arginine zipper which modulates the conformation of the CD loop. | ||
==About this Structure== | ==About this Structure== | ||
1BJ8 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | 1BJ8 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BJ8 OCA]. | ||
==Reference== | ==Reference== | ||
| Line 17: | Line 16: | ||
[[Category: Grotzinger, J.]] | [[Category: Grotzinger, J.]] | ||
[[Category: Grzesiek, S.]] | [[Category: Grzesiek, S.]] | ||
[[Category: Heinrich, P | [[Category: Heinrich, P C.]] | ||
[[Category: Kernebeck, T.]] | [[Category: Kernebeck, T.]] | ||
[[Category: Kurapkat, G.]] | [[Category: Kurapkat, G.]] | ||
[[Category: Muller-Newen, G.]] | [[Category: Muller-Newen, G.]] | ||
[[Category: Pflanz, S.]] | [[Category: Pflanz, S.]] | ||
[[Category: Scheek, R | [[Category: Scheek, R M.]] | ||
[[Category: Wollmer, A.]] | [[Category: Wollmer, A.]] | ||
[[Category: glycoprotein]] | [[Category: glycoprotein]] | ||
| Line 30: | Line 29: | ||
[[Category: transmembrane]] | [[Category: transmembrane]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:55:56 2008'' | ||
Revision as of 12:56, 21 February 2008
|
THIRD N-TERMINAL DOMAIN OF GP130, NMR, MINIMIZED AVERAGE STRUCTURE
OverviewOverview
The transmembrane glycoprotein gp130 is the common signal transducing receptor subunit of the interleukin-6-type cytokines. It is a member of the cytokine-receptor superfamily predicted to consist of six domains in its extracellular part. The second and third domain constitute the cytokine-binding module defined by a set of four conserved cysteines and a WSXWS motif, respectively. The three-dimensional structure of the carboxy-terminal domain of this region was determined by multidimensional NMR. The domain consists of seven beta-strands constituting a fibronectin type III-like topology. The structure reveals that the WSDWS motif of gp130 is part of an extended tryptophan/arginine zipper which modulates the conformation of the CD loop.
About this StructureAbout this Structure
1BJ8 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
The signal transducer gp130: solution structure of the carboxy-terminal domain of the cytokine receptor homology region., Kernebeck T, Pflanz S, Muller-Newen G, Kurapkat G, Scheek RM, Dijkstra K, Heinrich PC, Wollmer A, Grzesiek S, Grotzinger J, Protein Sci. 1999 Jan;8(1):5-12. PMID:10210178
Page seeded by OCA on Thu Feb 21 11:55:56 2008