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==Structure of CalU17 from the Calicheamicin Biosynthesis Pathway of Micromonospora echinospora== | ==Structure of CalU17 from the Calicheamicin Biosynthesis Pathway of Micromonospora echinospora== | ||
<StructureSection load='7msy' size='340' side='right'caption='[[7msy]]' scene=''> | <StructureSection load='7msy' size='340' side='right'caption='[[7msy]], [[Resolution|resolution]] 2.21Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7MSY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7MSY FirstGlance]. <br> | <table><tr><td colspan='2'>[[7msy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_15835_[[micromonospora_purpurea_luedemann_and_brodsky_1964_(approved_lists_1980)]] Atcc 15835 [[micromonospora purpurea luedemann and brodsky 1964 (approved lists 1980)]]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7MSY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7MSY FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7msy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7msy OCA], [https://pdbe.org/7msy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7msy RCSB], [https://www.ebi.ac.uk/pdbsum/7msy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7msy ProSAT]</span></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[7ml6|7ml6]], [[6vqp|6vqp]]</div></td></tr> | |||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">calU17 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1877 ATCC 15835 [[Micromonospora purpurea Luedemann and Brodsky 1964 (Approved Lists 1980)]]])</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7msy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7msy OCA], [https://pdbe.org/7msy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7msy RCSB], [https://www.ebi.ac.uk/pdbsum/7msy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7msy ProSAT]</span></td></tr> | |||
</table> | </table> | ||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Dynemicin is an enediyne natural product from Micromonospora chersina ATCC53710. Access to the biosynthetic gene cluster of dynemicin has enabled the in vitro study of gene products within the cluster to decipher their roles in assembling this unique molecule. This paper reports the crystal structure of DynF, the gene product of one of the genes within the biosynthetic gene cluster of dynemicin. DynF is revealed to be a dimeric eight-stranded beta-barrel structure with palmitic acid bound within a cavity. The presence of palmitic acid suggests that DynF may be involved in binding the precursor polyene heptaene, which is central to the synthesis of the ten-membered ring of the enediyne core. | |||
The crystal structure of DynF from the dynemicin-biosynthesis pathway of Micromonospora chersina.,Kosgei AJ, Miller MD, Bhardwaj M, Xu W, Thorson JS, Van Lanen SG, Phillips GN Jr Acta Crystallogr F Struct Biol Commun. 2022 Jan 1;78(Pt 1):1-7. doi:, 10.1107/S2053230X21012322. Epub 2022 Jan 1. PMID:34981769<ref>PMID:34981769</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 7msy" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Kosgei | [[Category: Kosgei, A J]] | ||
[[Category: Miller | [[Category: Lanen, S G.Van]] | ||
[[Category: Phillips | [[Category: Miller, M D]] | ||
[[Category: Thorson | [[Category: Phillips, G N]] | ||
[[Category: | [[Category: Thorson, J S]] | ||
[[Category: | [[Category: Xu, W]] | ||
[[Category: Calicheamicin biosynthesis]] | |||
[[Category: Enediyne biosynthetic pathway]] | |||
[[Category: Unknown function]] | |||