6ka2: Difference between revisions

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<StructureSection load='6ka2' size='340' side='right'caption='[[6ka2]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
<StructureSection load='6ka2' size='340' side='right'caption='[[6ka2]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6ka2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Opium_poppy Opium poppy]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KA2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6KA2 FirstGlance]. <br>
<table><tr><td colspan='2'>[[6ka2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Papaver_somniferum Papaver somniferum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KA2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6KA2 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=D4R:(4R,7aR,12bS)-7,9-dimethoxy-3-methyl-2,4,7a,13-tetrahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline'>D4R</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">THS2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3469 Opium poppy])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=D4R:(4R,7aR,12bS)-7,9-dimethoxy-3-methyl-2,4,7a,13-tetrahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline'>D4R</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Thebaine_synthase Thebaine synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.99.24 4.2.99.24] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ka2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ka2 OCA], [https://pdbe.org/6ka2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ka2 RCSB], [https://www.ebi.ac.uk/pdbsum/6ka2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ka2 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ka2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ka2 OCA], [https://pdbe.org/6ka2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ka2 RCSB], [https://www.ebi.ac.uk/pdbsum/6ka2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ka2 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/THS2_PAPSO THS2_PAPSO]] Catalyzes the formation of thebaine from (7S)-salutaridinol 7-O-acetate at the expense of labile hydroxylated by-products, which are preferentially produced by spontaneous allylic elimination. No visible activity toward (7S)-salutaridinol (at pH 7).<ref>PMID:29807982</ref>
[https://www.uniprot.org/uniprot/THS2_PAPSO THS2_PAPSO] Catalyzes the formation of thebaine from (7S)-salutaridinol 7-O-acetate at the expense of labile hydroxylated by-products, which are preferentially produced by spontaneous allylic elimination. No visible activity toward (7S)-salutaridinol (at pH 7).<ref>PMID:29807982</ref>  
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== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Opium poppy]]
[[Category: Papaver somniferum]]
[[Category: Thebaine synthase]]
[[Category: Chen CC]]
[[Category: Chen, C C]]
[[Category: Guo RT]]
[[Category: Guo, R T]]
[[Category: Huang JW]]
[[Category: Huang, J W]]
[[Category: Liu WD]]
[[Category: Liu, W D]]
[[Category: Xue J]]
[[Category: Xue, J]]
[[Category: Yu XJ]]
[[Category: Yu, X J]]
[[Category: Biosynthetic protein]]
[[Category: Crystallization]]
[[Category: Synthase]]

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