Protein crosslinks: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

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 ====Lysine-Cysteine NOS Bonds====
-*[[Lysine-cysteine NOS bonds]] as protein crosslinks were first reported in 2021 by Wensien ''et al.''<ref name="wensien2021">PMID: 33953398</ref>. They reported that following a search of the entire PDB, they "identified a number of proteins from all domains of life that are highly likely to possess one or more NOS bridges", to be detailed in a manuscript in preparation.
+*[[Lysine-cysteine NOS bonds]] as protein crosslinks were first reported in 2021 by Wensien ''et al.''<ref name="wensien2021">PMID: 33953398</ref>. They reported that following a search of the entire PDB, they "identified a number of proteins from all domains of life that are highly likely to possess one or more NOS bridges", to be detailed in a manuscript in preparation. However, because such bonds were not recognized before 2021, those that occur in published structures would have been overlooked.
 *Example: [[6zx4]] was analyzed in depth and provided the first documented case. Additional examples will be found in the lower left panel of FirstGlance when this example is viewed.
 *Visualization: [https://firstglance.jmol.org/fg.htm?mol=6zx4 View 6zx4 in FirstGlance]. If you see "<span style='color:#00d0a0;'>&#10148;&#10148;</span><u>Show more details</u>" in the [http://firstglance.jmol.org/where.htm#mit Molecule Information Tab], click on that.
 ==Artificial Crosslinks==