Protein crosslinks: Difference between revisions
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==Natural Crosslinks== | ==Natural Crosslinks== | ||
*<big>[[Disulfide bonds]]</big> are the most common protein crosslinks. About 23% of protein structures in the [[PDB]] have disulfide bonds (July, 2021<ref>In July, 2021, the PDB had ~180,000 entries. Advanced search at RCSB.Org for "Polymer molecuar features: polymer entity type = protein" and "Deposited entry features: Disulfide bond count per deposited model > 0" gave ~41,000 hits, or about 23%.</ref>). | *<big>[[Disulfide bonds]]</big> are the most common protein crosslinks. About 23% of protein structures in the [[PDB]] have disulfide bonds (July, 2021<ref>In July, 2021, the PDB had ~180,000 entries. Advanced search at RCSB.Org for "Polymer molecuar features: polymer entity type = protein" and "Deposited entry features: Disulfide bond count per deposited model > 0" gave ~41,000 hits, or about 23%.</ref>). Example: Insulin [[9ins]] has 2 interchain and one intrachain disulfide bonds. | ||
Example: Insulin [[9ins]] has 2 interchain and one intrachain disulfide bonds. | |||
**Visualization: [https://firstglance.jmol.org/fg.htm?mol=9ins View 9ins in FirstGlance]. In [[FirstGlance]], in the Tools tab, click Disulfides/S/Se. | **Visualization: [https://firstglance.jmol.org/fg.htm?mol=9ins View 9ins in FirstGlance]. In [[FirstGlance]], in the Tools tab, click Disulfides/S/Se. | ||