Thioester protein crosslinks: Difference between revisions

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</StructureSection>
</StructureSection>
==Other Protein Cross-Links==
Other covalent cross-links between polypeptide chains include:
*[[Disulfide bond]]s
*[[Isopeptide bond]]s
*[[Lysine-cysteine NOS bonds]]


==References==
==References==
<references />
<references />

Revision as of 02:55, 28 June 2021

Thioester bonds between cysteine and glutamine sidechains can form covalent cross-links between polypeptide chains.

  • Thioester bonds in complement proteins C3 and C4 are involved in tagging pathogens for destruction by the immune system, via the alternate complement activation pathway.
  • Thioester bonds occur in thioester domains (TED) of Gram-positive bacteria, where they are thought to mediate covalent adhesion of bacteria to host cells[1]. Many surface proteins of Gram-positive bacteria are predicted to contain TED as well as isopeptide and ester cross-links. This family of proteins is termed TIE proteins for thioester, isopeptide, ester proteins[1]. Examples: 2xi9, 6fwy.


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Other Protein Cross-LinksOther Protein Cross-Links

Other covalent cross-links between polypeptide chains include:


ReferencesReferences

  1. ↑ 1.0 1.1 Miller OK, Banfield MJ, Schwarz-Linek U. A new structural class of bacterial thioester domains reveals a slipknot topology. Protein Sci. 2018 Jul 27. doi: 10.1002/pro.3478. PMID:30052296 doi:http://dx.doi.org/10.1002/pro.3478

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