2oj6: Difference between revisions
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<StructureSection load='2oj6' size='340' side='right'caption='[[2oj6]], [[Resolution|resolution]] 1.85Å' scene=''> | <StructureSection load='2oj6' size='340' side='right'caption='[[2oj6]], [[Resolution|resolution]] 1.85Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2oj6]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Reovirus | <table><tr><td colspan='2'>[[2oj6]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Reovirus_sp. Reovirus sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OJ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OJ6 FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2oj6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oj6 OCA], [https://pdbe.org/2oj6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2oj6 RCSB], [https://www.ebi.ac.uk/pdbsum/2oj6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2oj6 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2oj6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oj6 OCA], [https://pdbe.org/2oj6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2oj6 RCSB], [https://www.ebi.ac.uk/pdbsum/2oj6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2oj6 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/SIGM1_REOVD SIGM1_REOVD] Fiber-like molecule that attaches the virion to the host cell membrane by binding to the primary receptor F11R/JAM-A and to sialic acid containing proteins (coreceptor). The interaction of sigma-1 with F11R is required for NF-kB activation and apoptosis. Binding to both sialic acid and F11R is required to induce maximal levels of apoptosis. | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Reovirus]] | [[Category: Reovirus sp]] | ||
[[Category: Dermody | [[Category: Dermody TS]] | ||
[[Category: Kirchner | [[Category: Kirchner E]] | ||
[[Category: Stehle | [[Category: Stehle T]] | ||