2oe3: Difference between revisions
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<StructureSection load='2oe3' size='340' side='right'caption='[[2oe3]], [[Resolution|resolution]] 1.80Å' scene=''> | <StructureSection load='2oe3' size='340' side='right'caption='[[2oe3]], [[Resolution|resolution]] 1.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2oe3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2oe3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OE3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OE3 FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2oe3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oe3 OCA], [https://pdbe.org/2oe3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2oe3 RCSB], [https://www.ebi.ac.uk/pdbsum/2oe3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2oe3 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2oe3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oe3 OCA], [https://pdbe.org/2oe3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2oe3 RCSB], [https://www.ebi.ac.uk/pdbsum/2oe3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2oe3 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/TRX3_YEAST TRX3_YEAST] | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Saccharomyces cerevisiae]] | ||
[[Category: | [[Category: Bao R]] | ||
[[Category: Chen YX]] | |||
[[Category: | [[Category: Zhang YR]] | ||
[[Category: | [[Category: Zhou CZ]] | ||
[[Category: | |||
Revision as of 11:57, 25 October 2023
Crystal Structure of Mitochondrial Thioredoxin 3 from Saccharomyces cerevisiae (oxidized form)Crystal Structure of Mitochondrial Thioredoxin 3 from Saccharomyces cerevisiae (oxidized form)
Structural highlights
FunctionEvolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMedThe yeast Saccharomyces cerevisiae Trx3 is a key member of the thioredoxin system to control the cellular redox homeostasis in mitochondria. We solved the crystal structures of yeast Trx3 in oxidized and reduced forms at 1.80 and 2.10 A, respectively. Besides the active site, the additional cysteine residue Cys69 also undergoes a significant redox-correlated conformational change. Comparative structural analyses in combination with activity assays revealed that residue Cys69 could be S-nitrosylated in vitro. S-nitrosylation of Cys69 will decrease the activity of Trx3 by 20%, which is comparable to the effect of the Cys69Ser mutation. Taken together, these findings provided us some new insights into the putative function of the additional cysteine residues of Trx3. Structural and mechanistic analyses of yeast mitochondrial thioredoxin Trx3 reveal putative function of its additional cysteine residues.,Bao R, Zhang Y, Zhou CZ, Chen Y Biochim Biophys Acta. 2009 Apr;1794(4):716-21. Epub 2009 Jan 3. PMID:19166985[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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