2o90: Difference between revisions

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<StructureSection load='2o90' size='340' side='right'caption='[[2o90]], [[Resolution|resolution]] 1.07&Aring;' scene=''>
<StructureSection load='2o90' size='340' side='right'caption='[[2o90]], [[Resolution|resolution]] 1.07&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2o90]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O90 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2O90 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2o90]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O90 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2O90 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NEU:L-NEOPTERIN'>NEU</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.07&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2nm2|2nm2]], [[2nm3|2nm3]], [[1dhn|1dhn]], [[2dhn|2dhn]], [[2oak|2oak]], [[2o9m|2o9m]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NEU:L-NEOPTERIN'>NEU</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">folB ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Dihydroneopterin_aldolase Dihydroneopterin aldolase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.2.25 4.1.2.25] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2o90 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o90 OCA], [https://pdbe.org/2o90 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2o90 RCSB], [https://www.ebi.ac.uk/pdbsum/2o90 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2o90 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2o90 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o90 OCA], [https://pdbe.org/2o90 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2o90 RCSB], [https://www.ebi.ac.uk/pdbsum/2o90 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2o90 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/FOLB_ECOLI FOLB_ECOLI]] Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin. Can use L-threo-dihydroneopterin and D-erythro-dihydroneopterin as substrates for the formation of 6-hydroxymethyldihydropterin, but it can also catalyze the epimerization of carbon 2' of dihydroneopterin and dihydromonapterin at appreciable velocity.  
[https://www.uniprot.org/uniprot/FOLB_ECOLI FOLB_ECOLI] Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin. Can use L-threo-dihydroneopterin and D-erythro-dihydroneopterin as substrates for the formation of 6-hydroxymethyldihydropterin, but it can also catalyze the epimerization of carbon 2' of dihydroneopterin and dihydromonapterin at appreciable velocity.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bacillus coli migula 1895]]
[[Category: Escherichia coli]]
[[Category: Dihydroneopterin aldolase]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Blaszczyk, J]]
[[Category: Blaszczyk J]]
[[Category: Ji, X]]
[[Category: Ji X]]
[[Category: Yan, H]]
[[Category: Yan H]]
[[Category: 8-dihydroneopterin]]
[[Category: Atomic resolution]]
[[Category: Dhna]]
[[Category: Drug design]]
[[Category: Lyase]]
[[Category: Monapterin]]
[[Category: Neopterin]]

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