2nlk: Difference between revisions
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<StructureSection load='2nlk' size='340' side='right'caption='[[2nlk]], [[Resolution|resolution]] 2.40Å' scene=''> | <StructureSection load='2nlk' size='340' side='right'caption='[[2nlk]], [[Resolution|resolution]] 2.40Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2nlk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2nlk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NLK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NLK FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nlk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nlk OCA], [https://pdbe.org/2nlk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nlk RCSB], [https://www.ebi.ac.uk/pdbsum/2nlk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nlk ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nlk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nlk OCA], [https://pdbe.org/2nlk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nlk RCSB], [https://www.ebi.ac.uk/pdbsum/2nlk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nlk ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/PTPRG_HUMAN PTPRG_HUMAN] Possesses tyrosine phosphatase activity.<ref>PMID:19167335</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Arrowsmith C]] | |||
[[Category: Arrowsmith | [[Category: Edwards A]] | ||
[[Category: Filippakopoulos P]] | |||
[[Category: Edwards | [[Category: Gileadi O]] | ||
[[Category: Filippakopoulos | [[Category: Johansson C]] | ||
[[Category: Gileadi | [[Category: Knapp S]] | ||
[[Category: Johansson | [[Category: Sundstrom M]] | ||
[[Category: Knapp | [[Category: Ugochukwu E]] | ||
[[Category: Von Delft F]] | |||
[[Category: Sundstrom | |||
[[Category: Ugochukwu | |||
[[Category: | |||
Latest revision as of 13:16, 30 August 2023
Crystal structure of D1 and D2 catalytic domains of human Protein Tyrosine Phosphatase Gamma (D1+D2 PTPRG)Crystal structure of D1 and D2 catalytic domains of human Protein Tyrosine Phosphatase Gamma (D1+D2 PTPRG)
Structural highlights
FunctionPTPRG_HUMAN Possesses tyrosine phosphatase activity.[1] Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMedProtein tyrosine phosphatases (PTPs) play a critical role in regulating cellular functions by selectively dephosphorylating their substrates. Here we present 22 human PTP crystal structures that, together with prior structural knowledge, enable a comprehensive analysis of the classical PTP family. Despite their largely conserved fold, surface properties of PTPs are strikingly diverse. A potential secondary substrate-binding pocket is frequently found in phosphatases, and this has implications for both substrate recognition and development of selective inhibitors. Structural comparison identified four diverse catalytic loop (WPD) conformations and suggested a mechanism for loop closure. Enzymatic assays revealed vast differences in PTP catalytic activity and identified PTPD1, PTPD2, and HDPTP as catalytically inert protein phosphatases. We propose a "head-to-toe" dimerization model for RPTPgamma/zeta that is distinct from the "inhibitory wedge" model and that provides a molecular basis for inhibitory regulation. This phosphatome resource gives an expanded insight into intrafamily PTP diversity, catalytic activity, substrate recognition, and autoregulatory self-association. Large-scale structural analysis of the classical human protein tyrosine phosphatome.,Barr AJ, Ugochukwu E, Lee WH, King ON, Filippakopoulos P, Alfano I, Savitsky P, Burgess-Brown NA, Muller S, Knapp S Cell. 2009 Jan 23;136(2):352-63. PMID:19167335[2] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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