2ndo: Difference between revisions
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==Structure of EcDsbA-sulfonamide1 complex== | ==Structure of EcDsbA-sulfonamide1 complex== | ||
<StructureSection load='2ndo' size='340' side='right'caption='[[2ndo | <StructureSection load='2ndo' size='340' side='right'caption='[[2ndo]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2ndo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2ndo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NDO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NDO FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SFQ:2-{[(4-IODOPHENYL)SULFONYL]AMINO}BENZOIC+ACID'>SFQ</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SFQ:2-{[(4-IODOPHENYL)SULFONYL]AMINO}BENZOIC+ACID'>SFQ</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ndo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ndo OCA], [https://pdbe.org/2ndo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ndo RCSB], [https://www.ebi.ac.uk/pdbsum/2ndo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ndo ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ndo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ndo OCA], [https://pdbe.org/2ndo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ndo RCSB], [https://www.ebi.ac.uk/pdbsum/2ndo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ndo ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/DSBA_ECOLI DSBA_ECOLI] Required for disulfide bond formation in some periplasmic proteins such as PhoA or OmpA. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbA is reoxidized by DsbB. Required for pilus biogenesis. PhoP-regulated transcription is redox-sensitive, being activated when the periplasm becomes more reducing (deletion of dsbA/dsbB, treatment with dithiothreitol). MgrB acts between DsbA/DsbB and PhoP/PhoQ in this pathway.<ref>PMID:1429594</ref> <ref>PMID:22267510</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Escherichia coli K-12]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Bermel | [[Category: Bermel W]] | ||
[[Category: Chalmers | [[Category: Chalmers DK]] | ||
[[Category: Doak | [[Category: Doak BC]] | ||
[[Category: Ilyichova | [[Category: Ilyichova O]] | ||
[[Category: King | [[Category: King GF]] | ||
[[Category: Mobli | [[Category: Mobli M]] | ||
[[Category: Scanlon | [[Category: Scanlon MJ]] | ||
[[Category: Simpson | [[Category: Simpson JS]] | ||
[[Category: Vazirani | [[Category: Vazirani M]] | ||
[[Category: Wang | [[Category: Wang G]] | ||
[[Category: Williams | [[Category: Williams ML]] | ||