6rod: Difference between revisions

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 ==Alpha-1-antitrypsin (Ser36Arg/Glu78Arg/Glu266Arg) in the native conformation==
-<StructureSection load='6rod' size='340' side='right'caption='[[6rod]]' scene=''>
+<StructureSection load='6rod' size='340' side='right'caption='[[6rod]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ROD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ROD FirstGlance]. <br>
+<table><tr><td colspan='2'>[[6rod]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ROD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ROD FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6rod FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rod OCA], [https://pdbe.org/6rod PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6rod RCSB], [https://www.ebi.ac.uk/pdbsum/6rod PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6rod ProSAT]</span></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6rod FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rod OCA], [https://pdbe.org/6rod PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6rod RCSB], [https://www.ebi.ac.uk/pdbsum/6rod PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6rod ProSAT]</span></td></tr>
 </table>
+== Disease ==
+[https://www.uniprot.org/uniprot/A1AT_HUMAN A1AT_HUMAN] Defects in SERPINA1 are the cause of alpha-1-antitrypsin deficiency (A1ATD) [MIM:[https://omim.org/entry/613490 613490]. A disorder whose most common manifestation is emphysema, which becomes evident by the third to fourth decade. A less common manifestation of the deficiency is liver disease, which occurs in children and adults, and may result in cirrhosis and liver failure. Environmental factors, particularly cigarette smoking, greatly increase the risk of emphysema at an earlier age.<ref>PMID:1905728</ref> <ref>PMID:2390072</ref> <ref>PMID:2227940</ref>
+== Function ==
+[https://www.uniprot.org/uniprot/A1AT_HUMAN A1AT_HUMAN] Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin.[:]<ref>PMID:1906855</ref> <ref>PMID:1406456</ref>   Short peptide from AAT: reversible chymotrypsin inhibitor. It also inhibits elastase, but not trypsin. Its major physiological function is the protection of the lower respiratory tract against proteolytic destruction by human leukocyte elastase (HLE).[:]<ref>PMID:1906855</ref> <ref>PMID:1406456</ref>
 ==See Also==
 *[[Alpha-1-antitrypsin 3D structures|Alpha-1-antitrypsin 3D structures]]
+== References ==
+<references/>
 __TOC__
 </StructureSection>
+[[Category: Homo sapiens]]
 [[Category: Large Structures]]
-[[Category: Wan, M, Ronzoni, R, Lomas, DA, Irving, JA]]
+[[Category: Irving JA]]
+[[Category: Lomas DA]]
+[[Category: Ronzoni R]]
+[[Category: Wan M]]