1ar2: Difference between revisions
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<StructureSection load='1ar2' size='340' side='right'caption='[[1ar2]], [[Resolution|resolution]] 2.80Å' scene=''> | <StructureSection load='1ar2' size='340' side='right'caption='[[1ar2]], [[Resolution|resolution]] 2.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1ar2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[1ar2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AR2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AR2 FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ar2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ar2 OCA], [https://pdbe.org/1ar2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ar2 RCSB], [https://www.ebi.ac.uk/pdbsum/1ar2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ar2 ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ar2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ar2 OCA], [https://pdbe.org/1ar2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ar2 RCSB], [https://www.ebi.ac.uk/pdbsum/1ar2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ar2 ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/KVD33_HUMAN KVD33_HUMAN] V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).<ref>PMID:17576170</ref> <ref>PMID:20176268</ref> <ref>PMID:22158414</ref> <ref>PMID:24600447</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Bes | [[Category: Bes MT]] | ||
[[Category: Fritz | [[Category: Fritz H-J]] | ||
[[Category: Hartsch | [[Category: Hartsch T]] | ||
[[Category: Schneider | [[Category: Schneider TR]] | ||
[[Category: Sheldrick | [[Category: Sheldrick GM]] | ||
[[Category: Uson | [[Category: Uson I]] | ||