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==NMR structure of the second and third lotus domains of tudor domain-containing protein 7 (NMR ensemble overlay for Lotus #2)==
==NMR structure of the second and third lotus domains of tudor domain-containing protein 7 (NMR ensemble overlay for Lotus #2)==
<StructureSection load='2ly1' size='340' side='right'caption='[[2ly1]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2ly1' size='340' side='right'caption='[[2ly1]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2ly1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LY1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LY1 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2ly1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LY1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LY1 FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2ly2|2ly2]]</div></td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ly1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ly1 OCA], [https://pdbe.org/2ly1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ly1 RCSB], [https://www.ebi.ac.uk/pdbsum/2ly1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ly1 ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Tdrd7, Pctaire2bp ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ly1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ly1 OCA], [https://pdbe.org/2ly1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ly1 RCSB], [https://www.ebi.ac.uk/pdbsum/2ly1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ly1 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/TDRD7_MOUSE TDRD7_MOUSE]] Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. Required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. Also required during spermatogenesis.<ref>PMID:21436445</ref>
[https://www.uniprot.org/uniprot/TDRD7_MOUSE TDRD7_MOUSE] Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. Required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. Also required during spermatogenesis.<ref>PMID:21436445</ref>  
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Lk3 transgenic mice]]
[[Category: Mus musculus]]
[[Category: Botuyan, M]]
[[Category: Botuyan M]]
[[Category: Cui, G]]
[[Category: Cui G]]
[[Category: Mer, G]]
[[Category: Mer G]]
[[Category: Germinal granule]]
[[Category: Lotus domain]]
[[Category: Ost-hth domain]]
[[Category: Rna binding domain]]
[[Category: Rna binding protein]]
[[Category: Tdrd7]]

Revision as of 16:18, 22 February 2023

NMR structure of the second and third lotus domains of tudor domain-containing protein 7 (NMR ensemble overlay for Lotus #2)NMR structure of the second and third lotus domains of tudor domain-containing protein 7 (NMR ensemble overlay for Lotus #2)

Structural highlights

2ly1 is a 1 chain structure with sequence from Mus musculus. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

TDRD7_MOUSE Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. Required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. Also required during spermatogenesis.[1]

References

  1. ↑ Lachke SA, Alkuraya FS, Kneeland SC, Ohn T, Aboukhalil A, Howell GR, Saadi I, Cavallesco R, Yue Y, Tsai AC, Nair KS, Cosma MI, Smith RS, Hodges E, Alfadhli SM, Al-Hajeri A, Shamseldin HE, Behbehani A, Hannon GJ, Bulyk ML, Drack AV, Anderson PJ, John SW, Maas RL. Mutations in the RNA granule component TDRD7 cause cataract and glaucoma. Science. 2011 Mar 25;331(6024):1571-6. doi: 10.1126/science.1195970. PMID:21436445 doi:10.1126/science.1195970
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