2c2o: Difference between revisions

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 <StructureSection load='2c2o' size='340' side='right'caption='[[2c2o]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2c2o]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C2O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C2O FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2c2o]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C2O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C2O FirstGlance]. <br>
-</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MX3:(1-{4-[BENZYL(METHYL)AMINO]-4-OXOBUTANOYL}HYDRAZINO)ACETIC+ACID'>MX3</scene>, <scene name='pdbligand=PHQ:BENZYL+CHLOROCARBONATE'>PHQ</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.45&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1cp3|1cp3]], [[1gfw|1gfw]], [[1i3o|1i3o]], [[1nme|1nme]], [[1nmq|1nmq]], [[1nms|1nms]], [[1pau|1pau]], [[1qx3|1qx3]], [[1re1|1re1]], [[1rhj|1rhj]], [[1rhk|1rhk]], [[1rhm|1rhm]], [[1rhq|1rhq]], [[1rhr|1rhr]], [[1rhu|1rhu]], [[2c1e|2c1e]], [[2c2k|2c2k]], [[2c2m|2c2m]], [[2cdr|2cdr]], [[2cjx|2cjx]], [[2cjy|2cjy]], [[2cnk|2cnk]], [[2cnl|2cnl]], [[2cnn|2cnn]], [[2cno|2cno]], [[2j30|2j30]], [[2j31|2j31]], [[2j32|2j32]], [[2j33|2j33]]</div></td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MX3:(1-{4-[BENZYL(METHYL)AMINO]-4-OXOBUTANOYL}HYDRAZINO)ACETIC+ACID'>MX3</scene>, <scene name='pdbligand=PHQ:BENZYL+CHLOROCARBONATE'>PHQ</scene></td></tr>
 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c2o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c2o OCA], [https://pdbe.org/2c2o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c2o RCSB], [https://www.ebi.ac.uk/pdbsum/2c2o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c2o ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[https://www.uniprot.org/uniprot/CASP3_HUMAN CASP3_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.<ref>PMID:7596430</ref> <ref>PMID:21357690</ref>
+[https://www.uniprot.org/uniprot/CASP3_HUMAN CASP3_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.<ref>PMID:7596430</ref> <ref>PMID:21357690</ref>
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 36: / Line 36: @@
 __TOC__
 </StructureSection>
+[[Category: Homo sapiens]]
 [[Category: Large Structures]]
-[[Category: Asgian, J L]]
+[[Category: Synthetic construct]]
-[[Category: Campbell, A]]
+[[Category: Asgian JL]]
-[[Category: Ekici, O D]]
+[[Category: Campbell A]]
-[[Category: Ganesan, R]]
+[[Category: Ekici OD]]
-[[Category: Gruetter, M G]]
+[[Category: Ganesan R]]
-[[Category: James, K E]]
+[[Category: Gruetter MG]]
-[[Category: Jelakovic, S]]
+[[Category: James KE]]
-[[Category: Li, Z Z]]
+[[Category: Jelakovic S]]
-[[Category: Mikolajczyk, J]]
+[[Category: Li ZZ]]
-[[Category: Powers, J C]]
+[[Category: Mikolajczyk J]]
-[[Category: Salvesen, G S]]
+[[Category: Powers JC]]
-[[Category: Apoptosis]]
+[[Category: Salvesen GS]]
-[[Category: Aza-asp]]
-[[Category: Aza-peptide]]
-[[Category: Clan cd]]
-[[Category: Cpp32]]
-[[Category: Cysteine-protease]]
-[[Category: Hydrolase-hydrolase inhibitor complex]]
-[[Category: Ice]]
-[[Category: Michael acceptor]]
-[[Category: Tetramer]]
-[[Category: Thiol protease]]
-[[Category: Yama]]
-[[Category: Zymogen]]