2gtt: Difference between revisions

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 <StructureSection load='2gtt' size='340' side='right'caption='[[2gtt]], [[Resolution|resolution]] 3.49&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2gtt]] is a 24 chain structure with sequence from [https://en.wikipedia.org/wiki/Rabies_virus Rabies virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GTT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GTT FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2gtt]] is a 24 chain structure with sequence from [https://en.wikipedia.org/wiki/Rabies_lyssavirus Rabies lyssavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GTT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GTT FirstGlance]. <br>
 </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gtt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gtt OCA], [https://pdbe.org/2gtt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gtt RCSB], [https://www.ebi.ac.uk/pdbsum/2gtt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gtt ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[https://www.uniprot.org/uniprot/NCAP_RABVE NCAP_RABVE]] Encapsidates the genome in a ratio of one protein N per nine ribonucleotides, protecting it from nucleases. If expressed without protein P it binds non-specifically RNA and therefore can bind it's own mRNA. Interaction with protein P abolishes any non-specific RNA binding, and prevents phosphorylation. The soluble N-P complex encapsidates specifically the genomic RNA, with protein N protecting the genome like a pearl necklace. The encapsidated genomic RNA is termed the nucleocapsid (NC) and serves as template for viral transcription and replication. Protein N binds protein P in the NC through a different interaction, and can be phosphorylated. Subsequent viral replication is dependent on intracellular concentration of newly synthesized protein N. During replication, encapsidation by protein N is coupled to RNA synthesis and all replicative products are resistant to nucleases (By similarity).
+[https://www.uniprot.org/uniprot/NCAP_RABVE NCAP_RABVE] Encapsidates the genome in a ratio of one protein N per nine ribonucleotides, protecting it from nucleases. If expressed without protein P it binds non-specifically RNA and therefore can bind it's own mRNA. Interaction with protein P abolishes any non-specific RNA binding, and prevents phosphorylation. The soluble N-P complex encapsidates specifically the genomic RNA, with protein N protecting the genome like a pearl necklace. The encapsidated genomic RNA is termed the nucleocapsid (NC) and serves as template for viral transcription and replication. Protein N binds protein P in the NC through a different interaction, and can be phosphorylated. Subsequent viral replication is dependent on intracellular concentration of newly synthesized protein N. During replication, encapsidation by protein N is coupled to RNA synthesis and all replicative products are resistant to nucleases (By similarity).
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
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 </StructureSection>
 [[Category: Large Structures]]
-[[Category: Rabies virus]]
+[[Category: Rabies lyssavirus]]
-[[Category: Albertini, A A.V]]
+[[Category: Albertini AAV]]
-[[Category: Muziol, T]]
+[[Category: Muziol T]]
-[[Category: Ravelli, R B.G]]
+[[Category: Ravelli RBG]]
-[[Category: Ruigrok, R W.H]]
+[[Category: Ruigrok RWH]]
-[[Category: Weissenhorn, W]]
+[[Category: Weissenhorn W]]
-[[Category: Wernimont, A K]]
+[[Category: Wernimont AK]]
-[[Category: Nucleoprotein]]
-[[Category: Protein-rna complex]]
-[[Category: Rna binding protein]]
-[[Category: Viral protein]]