1mpv: Difference between revisions
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==Structure of bhpBR3, the BAFF-binding loop of BR3 embedded in a beta-hairpin peptide== | ==Structure of bhpBR3, the BAFF-binding loop of BR3 embedded in a beta-hairpin peptide== | ||
<StructureSection load='1mpv' size='340' side='right'caption='[[1mpv | <StructureSection load='1mpv' size='340' side='right'caption='[[1mpv]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1mpv]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MPV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MPV FirstGlance]. <br> | <table><tr><td colspan='2'>[[1mpv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MPV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MPV FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mpv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mpv OCA], [https://pdbe.org/1mpv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mpv RCSB], [https://www.ebi.ac.uk/pdbsum/1mpv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mpv ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mpv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mpv OCA], [https://pdbe.org/1mpv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mpv RCSB], [https://www.ebi.ac.uk/pdbsum/1mpv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mpv ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | == Disease == | ||
[https://www.uniprot.org/uniprot/TR13C_HUMAN TR13C_HUMAN] Defects in TNFRSF13C are the cause of immunodeficiency common variable type 4 (CVID4) [MIM:[https://omim.org/entry/613494 613494]; also called antibody deficiency due to BAFFR defect. CVID4 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low.<ref>PMID:19666484</ref> | |||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/TR13C_HUMAN TR13C_HUMAN] B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response.<ref>PMID:11591325</ref> <ref>PMID:12387744</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Cochran | [[Category: Cochran AG]] | ||
[[Category: Dixit | [[Category: Dixit VM]] | ||
[[Category: French | [[Category: French DM]] | ||
[[Category: Gordon | [[Category: Gordon NC]] | ||
[[Category: Grewal | [[Category: Grewal IS]] | ||
[[Category: Kayagaki | [[Category: Kayagaki N]] | ||
[[Category: Lee | [[Category: Lee W]] | ||
[[Category: Seshasayee | [[Category: Seshasayee D]] | ||
[[Category: Starovasnik | [[Category: Starovasnik MA]] | ||
[[Category: Wang | [[Category: Wang H]] | ||
[[Category: Yan | [[Category: Yan M]] | ||
[[Category: Yin | [[Category: Yin J]] | ||
Revision as of 21:50, 29 November 2023
Structure of bhpBR3, the BAFF-binding loop of BR3 embedded in a beta-hairpin peptideStructure of bhpBR3, the BAFF-binding loop of BR3 embedded in a beta-hairpin peptide
Structural highlights
DiseaseTR13C_HUMAN Defects in TNFRSF13C are the cause of immunodeficiency common variable type 4 (CVID4) [MIM:613494; also called antibody deficiency due to BAFFR defect. CVID4 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low.[1] FunctionTR13C_HUMAN B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response.[2] [3] Publication Abstract from PubMedThe TNF-like ligand BAFF/BLyS is a potent survival factor for B cells. It binds three receptors: TACI, BCMA, and BR3. We show that BR3 signaling promotes processing of the transcription factor NF-kappaB2/p100 to p52. NF-kappaB2/p100 cleavage was abrogated in B cells from A/WySnJ mice possessing a mutant BR3 gene, but not in TACI or BCMA null B cells. Furthermore, wild-type mice injected with BAFF-neutralizing BR3-Fc protein showed reduced basal NF-kappaB2 activation. BR3-Fc treatment of NZB/WF1 mice, which develop a fatal lupus-like syndrome, inhibited NF-kappaB2 processing and attenuated the disease process. Since inhibiting the BR3-BAFF interaction has therapeutic ramifications, the ligand binding interface of BR3 was investigated and found to reside within a 26 residue core domain. When stabilized within a structured beta-hairpin peptide, six of these residues were sufficient to confer binding to BAFF. BAFF/BLyS receptor 3 binds the B cell survival factor BAFF ligand through a discrete surface loop and promotes processing of NF-kappaB2.,Kayagaki N, Yan M, Seshasayee D, Wang H, Lee W, French DM, Grewal IS, Cochran AG, Gordon NC, Yin J, Starovasnik MA, Dixit VM Immunity. 2002 Oct;17(4):515-24. PMID:12387744[4] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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