SARS-CoV-2 spike protein fusion transformation: Difference between revisions

Karsten Theis (talk | contribs)
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[[Image:Spike protein fusion mainchain morph from Proteopedia.Org.gif]]
[[Image:Spike protein fusion mainchain morph from Proteopedia.Org.gif]]


===Alternate Main Chain Fusion Transformtion===
===Alternate Pathway for Transformation===
Given that a [[morph]] is intended to help you compare two structures and does NOT portray a realistic transition pathway, there are many pathways we can imagine. Below is another one that has structural elements swing away from the core structure in a hinge motion as they change conformation. Another choice in this morph is to have different timings for the distinct changes to be able to follow them one at a time.
Given that a [[morph]] is intended to help you compare two structures and does not portray a realistic transition pathway, there are many pathways we can imagine. Below is another one that has structural elements swing away from the core structure in a hinge motion as they change conformation. Another choice in this morph is to have different timings for the distinct changes to be able to follow them one at a time.


In the morph at full resolution, you can see a large cavity disappearing, the beta sheets acquiring an additional strand from a different subunit (subunits shown in green, blue and red tints), and changes in the core helix bundle along with the formation of the triple helix protrusion.
In the morph at full resolution, you can see a large cavity disappearing, the beta sheets acquiring an additional strand from a different subunit (subunits shown in green, blue and red tints), and changes in the core helix bundle along with the formation of the triple helix protrusion.

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Eric Martz, Karsten Theis