SARS-CoV-2 spike protein fusion transformation: Difference between revisions
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===Alternate Main Chain Fusion Transformtion=== | ===Alternate Main Chain Fusion Transformtion=== | ||
Given that a [[morph]] is intended to help you compare two structures and does NOT portray a realistic transition pathway, there are many pathways we can imagine. Below is another one that has structural elements swing away from the core structure in a hinge motion as they change conformation. Another choice in this morph is to have different timings for the distinct changes to be able to follow them one at a time. | Given that a [[morph]] is intended to help you compare two structures and does NOT portray a realistic transition pathway, there are many pathways we can imagine. Below is another one that has structural elements swing away from the core structure in a hinge motion as they change conformation. Another choice in this morph is to have different timings for the distinct changes to be able to follow them one at a time. | ||
In the morph, you can see a large cavity disappearing, the beta sheets acquiring an additional strand from a different subunit (subunits shown in green, blue and red tints), and changes in the core helix bundle along with the formation of the triple helix protrusion. | |||
'''[https://proteopedia.org/wiki/images/e/ef/Spike_storymorph.gif Download] (right click, save link as)''' 720 px wide main chain animation. This shows a smoothed main chain (backbone) trace. Please credit '''Proteopedia.Org''' in accord with our [[Proteopedia:Terms of Service|license]], and '''Cai, Zhang and coworkers<ref name="cai-zhang" />''' for their cryo-EM structures.<br> | '''[https://proteopedia.org/wiki/images/e/ef/Spike_storymorph.gif Download] (right click, save link as)''' 720 px wide main chain animation. This shows a smoothed main chain (backbone) trace. Please credit '''Proteopedia.Org''' in accord with our [[Proteopedia:Terms of Service|license]], and '''Cai, Zhang and coworkers<ref name="cai-zhang" />''' for their cryo-EM structures.<br> | ||