NADPH oxidase: Difference between revisions
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==Introduction== | ==Introduction== | ||
<StructureSection load='6SZ5' size='340' side='right' caption='Calmodulin bonded to a NOX-5 peptide' scene=''> | <StructureSection load='6SZ5' size='340' side='right' caption='Calmodulin bonded to a NOX-5 peptide (PDB code [[6sz5]])' scene=''> | ||
NADPH oxidase in its entirety leads to the release of reactive oxygen species; this process is called oxidative burst, where the eradication of invading microorganisms in macrophages and neutrophils ensues. NADPH oxidase is important in the maintenance of immune function, apoptosis, and cell growth. In previous times it was believed that NADPH oxidase generation of superoxides was only to happen in phagocytes, but inconsequent research studies, there are many enzymes that are responsible for reactive oxygen species production. For example, in kidneys, reactive oxygen species are produced from NOX3, and those molecules monitor renal function through sodium transport and oxygenation. Adding on, oxygen radicals increase sodium chloride absorption in the loop of Henle, which results in the regulation of sodium and hydrogen ion exchange. NADPH oxidase is known to function itself as a bacteria killer from the production of bacterial oxygen species by using oxygen and NADPH as substrates. In general, NADPH oxidase generates superoxides by moving electrons from NADPH inside of a cell and conjugating the oxygen atom to make superoxides | '''NADPH oxidase''' in its entirety leads to the release of reactive oxygen species; this process is called oxidative burst, where the eradication of invading microorganisms in macrophages and neutrophils ensues. NADPH oxidase is important in the maintenance of immune function, apoptosis, and cell growth. In previous times it was believed that NADPH oxidase generation of superoxides was only to happen in phagocytes, but inconsequent research studies, there are many enzymes that are responsible for reactive oxygen species production. For example, in kidneys, reactive oxygen species are produced from NOX3, and those molecules monitor renal function through sodium transport and oxygenation. Adding on, oxygen radicals increase sodium chloride absorption in the loop of Henle, which results in the regulation of sodium and hydrogen ion exchange. NADPH oxidase is known to function itself as a bacteria killer from the production of bacterial oxygen species by using oxygen and NADPH as substrates. In general, NADPH oxidase generates superoxides by moving electrons from NADPH inside of a cell and conjugating the oxygen atom to make superoxides | ||
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