Postsynaptic density protein: Difference between revisions
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1.Media Prefrontal Cortex - Under normal circumstances, PSD-95 continues to increase from birth until peaking during adolescents. However, if the PSD-95 is decreased, it will affect the medial prefrontal cortex (mPFC) which is responsible for cognition, working memory, and sociability (Coley, 2019). Researchers found that the PSD-95 knockout mice lacked sociability and exhibited both learning and working memory deficiencies. The dysfunction of PSD-95 is believed to manifest to some degree in humans as either schizophrenia or as autism <ref> DOI: 10.1038/s41598-019-45971-w </ref>. It has also been linked to Alzheimer’s by a research study. | 1.Media Prefrontal Cortex - Under normal circumstances, PSD-95 continues to increase from birth until peaking during adolescents. However, if the PSD-95 is decreased, it will affect the medial prefrontal cortex (mPFC) which is responsible for cognition, working memory, and sociability (Coley, 2019). Researchers found that the PSD-95 knockout mice lacked sociability and exhibited both learning and working memory deficiencies. The dysfunction of PSD-95 is believed to manifest to some degree in humans as either schizophrenia or as autism <ref> DOI: 10.1038/s41598-019-45971-w </ref>. It has also been linked to Alzheimer’s by a research study. | ||
2.Superior Temporal Sulcus - This research study focused on the superior temporal sulcus. The disease is mainly characterized by neuronal damage, neuronal death, and brain atrophy. The study found that in a group of post-mortem subjects; demented subjects had 50% less PSD-95 concentration than the control group | 2.Superior Temporal Sulcus - This research study focused on the superior temporal sulcus. The disease is mainly characterized by neuronal damage, neuronal death, and brain atrophy. The study found that in a group of post-mortem subjects; demented subjects had 50% less PSD-95 concentration than the control group. <ref> DOI: 10.1093/brain/awt171 </ref> This was compared to a group that had many of the same morphological signs as those with Alzheimer’s but suffered no adverse effects from it. This group had significantly more PSD-95 than a normal brain, perhaps to counter act the degrading aspects. | ||
3.Corpus Striatum – A study of cocaine abuse using a mice study suggests that psychostimulants decrease the PSD-95 levels in both the dorsal and ventral portions of the striatum though the hippocampus and cortex were unaffected. While less than 2 injections made little change in PSD-95 levels, 3 to 10 injections resulted in substantial chronic PSD-95 loss; however, 11 or more injections showed no additional decreases (Yao et al., 2004). When studied months after the last injection, the deficits in PSD-95 remained, suggesting long-term neuronal effects of drug use. | 3.Corpus Striatum – A study of cocaine abuse using a mice study suggests that psychostimulants decrease the PSD-95 levels in both the dorsal and ventral portions of the striatum though the hippocampus and cortex were unaffected. While less than 2 injections made little change in PSD-95 levels, 3 to 10 injections resulted in substantial chronic PSD-95 loss; however, 11 or more injections showed no additional decreases (Yao et al., 2004). When studied months after the last injection, the deficits in PSD-95 remained, suggesting long-term neuronal effects of drug use. | ||