Sandbox GGC6: Difference between revisions
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== Disease == | == Disease == | ||
NT-4, along with other growth factors including neurotrophin-3 (NT-3), brain-derived neurotrophic factor (BDNF), and nerve growth factor (NGF) have all shown to be essential for survival of neurons. These growth factors have | NT-4, along with other growth factors including neurotrophin-3 (NT-3), brain-derived neurotrophic factor (BDNF), and nerve growth factor (NGF) have all shown to be essential for survival of neurons. <ref>PMID: 10631974<ref/> <ref>PMID: 16411893</ref> These growth factors have been associated with parts of the cerebrum including the frontal lobe and limbic system because of their involvement in neurological processes like behavior, learning, and memory. <ref>PMID: 16411893</ref> | ||
== Relevance == | == Relevance == | ||
Revision as of 17:42, 28 April 2021
Neurotrophin-4Neurotrophin-4
Neurotrophin-4 (NT-4) is a neuronal growth factor that influences nerve cell proliferation through selective and non-covalent interactions with the nerve growth factor receptor.
FunctionNT-4 functions as a growth factor in many biological pathways and processes to induce neuronal proliferation. Biological ProcessesPositive regulation of neurotrophin TRK receptor signaling pathway: NT-4 functions as a ligand when binding to neurotrophin receptor tyrosine kinase NTRK2. Auto-phosphorylated NTRK2 dimers that are formed on tyrosine residues in receptor tail as a result of NT-4 binding. Neuron projection morphogenesis: Generating projection structures of a neuron,. Ganglion mother cell fate determination, epidermis development, innervation Nerve invading tissue and coming out DiseaseNT-4, along with other growth factors including neurotrophin-3 (NT-3), brain-derived neurotrophic factor (BDNF), and nerve growth factor (NGF) have all shown to be essential for survival of neurons. Cite error: Closing RelevanceStructural highlightsThis is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
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ReferencesReferences
- ↑ Chao MV, Rajagopal R, Lee FS. Neurotrophin signalling in health and disease. Clin Sci (Lond). 2006 Feb;110(2):167-73. doi: 10.1042/CS20050163. PMID:16411893 doi:http://dx.doi.org/10.1042/CS20050163