Sandbox GGC9: Difference between revisions
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Recent studies identified aspartic acid residues at positions 600 and 708 function to initiate catalysis.[7] | Recent studies identified aspartic acid residues at positions 600 and 708 function to initiate catalysis.[7] | ||
<scene name='75/752271/Catalytic_residues/1'>Catalytic Residues</scene> | <scene name='75/752271/Catalytic_residues/1'>Catalytic Residues</scene> | ||
In addition to the catalytic function of aspartic acid residues at 600 and 708, researchers have discovered a trio of residues that are necessary for the DNA cleavage during V(D)J recombination. This trio includes the two catalytic residues as well as a Glutamic acid residue at position 962. | |||
<scene name='75/752271/Dde_motif/1'>Residues responsible for DNA cleavage</scene> | |||
</StructureSection> | </StructureSection> | ||