1n4x: Difference between revisions
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<StructureSection load='1n4x' size='340' side='right'caption='[[1n4x]], [[Resolution|resolution]] 1.70Å' scene=''> | <StructureSection load='1n4x' size='340' side='right'caption='[[1n4x]], [[Resolution|resolution]] 1.70Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1n4x]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[1n4x]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N4X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1N4X FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1n4x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n4x OCA], [https://pdbe.org/1n4x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1n4x RCSB], [https://www.ebi.ac.uk/pdbsum/1n4x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1n4x ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1n4x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n4x OCA], [https://pdbe.org/1n4x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1n4x RCSB], [https://www.ebi.ac.uk/pdbsum/1n4x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1n4x ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/KV2A7_MOUSE KV2A7_MOUSE] | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Mus musculus]] | ||
[[Category: Bentley | [[Category: Bentley GA]] | ||
[[Category: Brynda | [[Category: Brynda J]] | ||
[[Category: Fabry | [[Category: Fabry M]] | ||
[[Category: Horejsi | [[Category: Horejsi M]] | ||
[[Category: Lescar | [[Category: Lescar J]] | ||
[[Category: Rezacova | [[Category: Rezacova P]] | ||
[[Category: Sedlacek | [[Category: Sedlacek J]] | ||
Latest revision as of 12:47, 21 December 2022
Structure of scFv 1696 at acidic pHStructure of scFv 1696 at acidic pH
Structural highlights
FunctionEvolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMedThe monoclonal antibody 1696, which was raised against the HIV-1 protease, inhibits the catalytic activity of the enzyme from both the HIV-1 and HIV-2 strains. The antibody cross-reacts with peptides containing the N-terminus of the enzyme, which is highly conserved between these strains. The crystal structure of a single-chain Fv fragment of 1696 (scFv-1696) in the non-complexed form, solved at 1.7 A resolution, is compared with the previously reported non-complexed Fab-1696 and antigen-bound scFv-1696 structures. Large conformational changes in the third hypervariable region of the heavy chain and differences in relative orientation of the variable domains are observed between the different structures. Structure of a single-chain Fv fragment of an antibody that inhibits the HIV-1 and HIV-2 proteases.,Lescar J, Brynda J, Fabry M, Horejsi M, Rezacova P, Sedlacek J, Bentley GA Acta Crystallogr D Biol Crystallogr. 2003 May;59(Pt 5):955-7. Epub 2003, Apr 25. PMID:12777823[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences |
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