2l1h: Difference between revisions
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==Mouse prion protein fragment 121-231 at 20 C== | ==Mouse prion protein fragment 121-231 at 20 C== | ||
<StructureSection load='2l1h' size='340' side='right'caption='[[2l1h | <StructureSection load='2l1h' size='340' side='right'caption='[[2l1h]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2l1h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2l1h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L1H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L1H FirstGlance]. <br> | ||
</td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l1h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l1h OCA], [https://pdbe.org/2l1h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l1h RCSB], [https://www.ebi.ac.uk/pdbsum/2l1h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l1h ProSAT]</span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l1h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l1h OCA], [https://pdbe.org/2l1h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l1h RCSB], [https://www.ebi.ac.uk/pdbsum/2l1h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l1h ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Disease == | |||
[https://www.uniprot.org/uniprot/PRIO_MOUSE PRIO_MOUSE] Note=Found in high quantity in the brain of humans and animals infected with degenerative neurological diseases such as kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome (GSS), scrapie, bovine spongiform encephalopathy (BSE), transmissible mink encephalopathy (TME), etc. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/PRIO_MOUSE PRIO_MOUSE] May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains.<ref>PMID:12732622</ref> <ref>PMID:16492732</ref> <ref>PMID:19242475</ref> <ref>PMID:19568430</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Mus musculus]] | ||
[[Category: Christen | [[Category: Christen B]] | ||
[[Category: Damberger | [[Category: Damberger FF]] | ||
[[Category: Hornemann | [[Category: Hornemann S]] | ||
[[Category: Perez | [[Category: Perez DR]] | ||
[[Category: Wuthrich | [[Category: Wuthrich K]] | ||