User:Tori Templin/Sandbox 1: Difference between revisions

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[https://en.wikipedia.org/wiki/Sterol_O-acyltransferase ACAT] is an important enzyme that catalyzes the esterification of cholesterol to form cholesterol esters, and it belongs to the class of enzymes called acyltransferases. It is also a member of the [https://en.wikipedia.org/wiki/MBOAT MBOAT] family because it is key in lipid metabolism. This enzyme is biologically important because it affects the solubility of cholesterol in the cell membrane and promotes accumulation of cholesterol ester in the cytoplasm as fat droplets. Accumulation of cholesterol ester as these lipid droplets is a main characteristic of macrophage foaming, which can lead to atherosclerotic diseases <ref name=”Qian”>PMID:32433614</ref>.  
[https://en.wikipedia.org/wiki/Sterol_O-acyltransferase ACAT] is an important enzyme that catalyzes the esterification of cholesterol to form cholesterol esters, and it belongs to the class of enzymes called acyltransferases. It is also a member of the [https://en.wikipedia.org/wiki/MBOAT MBOAT] family because it is key in lipid metabolism. This enzyme is biologically important because it affects the solubility of cholesterol in the cell membrane and promotes accumulation of cholesterol ester in the cytoplasm as fat droplets. Accumulation of cholesterol ester as these lipid droplets is a main characteristic of macrophage foaming, which can lead to atherosclerotic diseases <ref name=”Qian”>PMID:32433614</ref>.  


[[Image:   |400 px|right|thumb|Figure 2. Dimer in the Membrane]]
[[Image:Screen Shot 2021-04-13 at 2.31.40 PM.png|400 px|right|thumb|Figure 2. Dimer in the Membrane]]


SOAT article <ref name=”Chengcheng”>PMID:32424158</ref>
SOAT article <ref name=”Chengcheng”>PMID:32424158</ref>