2ke5: Difference between revisions
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==Solution structure and dynamics of the small GTPase Ralb in its active conformation: significance for effector protein binding== | ==Solution structure and dynamics of the small GTPase Ralb in its active conformation: significance for effector protein binding== | ||
<StructureSection load='2ke5' size='340' side='right'caption='[[2ke5 | <StructureSection load='2ke5' size='340' side='right'caption='[[2ke5]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2ke5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2ke5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KE5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KE5 FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ke5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ke5 OCA], [https://pdbe.org/2ke5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ke5 RCSB], [https://www.ebi.ac.uk/pdbsum/2ke5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ke5 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ke5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ke5 OCA], [https://pdbe.org/2ke5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ke5 RCSB], [https://www.ebi.ac.uk/pdbsum/2ke5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ke5 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/RALB_HUMAN RALB_HUMAN] Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells. Plays a role in the late stages of cytokinesis and is required for the abscission of the bridge joining the sister cells emerging from mitosis. Required for suppression of apoptosis.<ref>PMID:18756269</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Camonis | [[Category: Camonis J]] | ||
[[Category: Campbell | [[Category: Campbell LJ]] | ||
[[Category: Evetts | [[Category: Evetts KA]] | ||
[[Category: Fenwick | [[Category: Fenwick R]] | ||
[[Category: Mott | [[Category: Mott HR]] | ||
[[Category: Nietlispach | [[Category: Nietlispach D]] | ||
[[Category: Owen | [[Category: Owen D]] | ||
[[Category: Prasannan | [[Category: Prasannan S]] | ||